Evidence map›Paper›PMID 30128763›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2018

Intervertebral disc needle puncture injury can be repaired using a gelatin-poly (γ-glutamic acid) hydrogel: an in vitro bovine biomechanical validation.

Jui-Jung Yang, Frank Li, Kun-Che Hung, Shan-Hui Hsu, Jaw-Lin Wang

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  10. Nucleus replacement could get a new chance with annulus closure.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jui-Jung YangInstitute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan, ROC.ORCID 0000-0002-0866-4149
Frank LiInstitute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Kun-Che HungInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Shan-Hui HsuInstitute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Jaw-Lin WangInstitute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan, ROC. jlwang@ntu.edu.tw.
National Taiwan University · TWTri-Service General Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 104-2221-E-002 -121 -MY3Ministry of Science and Technology, Taiwan MOST 104-2221-E-002 -212 -MY3Ministry of Science and Technology, Taiwan MOST 104-2314-B-016-001
6 · The paper itself

Abstract

purposeThe subtle impairments of the disc due to anular punctures may have an immediate effect on the functional integrity due to the altered intradiscal pressure, hence the subsequent catabolic degradation. This study evaluates functional restoration of needle puncture injured intervertebral discs with a newly developed injectable hydrogel using the quantitative discomanometry (QD) test. The proposed hydrogel is composed of gelatin and poly (γ-glutamic acid) (γ-PGA) and crosslinked with 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDC).

methodsThirty-six bovine motion segments were distributed into six groups. Needle puncture injured discs were created in all discs except for those in the first group (intact). The second group included injured discs that received no treatment (injury). The remaining four groups included injured discs repaired with injected hydrogels fabricated with different polymer solutions and EDC concentrations including: gelatin/γ-PGA solution crosslinked with the EDC solution at a 10:1 and 40:1 ratio to form the GP/E(10:1) and GP/E(40:1) groups, respectively, and gelatin and γ-PGA solution crosslinked with the EDC solution at a 10:1 ratio to form the G/E(10:1) or P/E(10:1) groups. The QD tests were performed to evaluate disc integrity of all six groups.

resultsAmong all hydrogel repair groups, the GP/E(10:1) group was found to have the highest leakage and saturate pressure and was the only group comparable to the intact one.

conclusionsRestoration of disc integrity secondary to needle puncture injury can be achieved via the repair with the newly developed gelatin hydrogel incorporated with γ-PGA and EDC. These slides can be retrieved under Electronic Supplementary Material.

Indexed as

GelatinHydrogelsIntervertebral DiscPolyglutamic AcidAnimalsBiomechanical PhenomenaCattleDrug CombinationsNeedlesDrug CombinationsGelatingelatin-polyglutamic acid glueHydrogelsPolyglutamic AcidAnulus fibrosus repairFilling sealantGelatin–poly (γ-glutamic acid) injectable hydrogelIntradiscal pressureQuantitative discomanometry

Identifiers

PMID30128763
OpenAlexW2888351831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.