Evidence map›Paper›PMID 30128739›Full record

ArticleCancer immunology, immunotherapy : CII2018

IL-10 inducible CD8

Julian Plaumann, Melanie Engelhardt, Mohamed H S Awwad, Hakim Echchannaoui, Eva Amman, Marc S Raab, Jens Hillengass, Niels Halama, Brigitte Neuber, Carsten Müller-Tidow and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. CD8Leukemia · 2024
    Trial
  2. Article
  3. Review
  4. Regulatory T Cell-Based Adoptive Cell Therapy in Autoimmunity.International journal of molecular sciences · 2025
    Review
  5. T Cells Dysfunction in Multiple Myeloma.ImmunoTargets and therapy · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Accumulation of CD28Biomolecules · 2021
    Review
  12. Article
  13. T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Article
  14. Article
  15. Article
  16. The Evolving Role of CD8International journal of molecular sciences · 2019
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Julian PlaumannDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Melanie EngelhardtDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Mohamed H S AwwadDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Hakim EchchannaouiDepartment of Hematology, Oncology and Pneumology, University Medical Center (UMC) of the Johannes Gutenberg University Mainz, Mainz, Germany.
Eva AmmanDepartment of Hematology, Oncology and Pneumology, University Medical Center (UMC) of the Johannes Gutenberg University Mainz, Mainz, Germany.
Marc S RaabDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Jens HillengassDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Niels HalamaNational Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Brigitte NeuberDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Carsten Müller-TidowDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Hartmut GoldschmidtDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.
Michael HundemerDepartment of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany. Michael.Hundemer@med.uni-heidelberg.de.
Heidelberg University · DENational Center for Tumor Diseases · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8

Indexed as

Case-Control StudiesCD28 AntigensCD8 AntigensCD8-Positive T-LymphocytesCells, CulturedHumansInterleukin-10Lymphocyte ActivationMultiple MyelomaParaproteinemiasT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsCD28 AntigensCD8 AntigensIL10 protein, humanInterleukin-10CD57+IL-10LFA-1Multiple myeloma

Identifiers

PMID30128739
PMCPMC11028289
OpenAlexW2888172749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.