ArticleJournal of abnormal child psychology2019
A Phenotype of Childhood Autism Is Associated with Preexisting Maternal Anxiety and Depression.
Article in Journal of abnormal child psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Association of parental prenatal mental health with offspring neurodevelopmental disorders: a systematic review and meta-analysis.Psychological medicine · 2026Pooled it
- Association between Maternal Anxiety and Children's Problem Behaviors: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Trial
- Child Autism Spectrum Disorder Following Maternal Abuse and Trauma History.Journal of autism and developmental disorders · 2026Article
- Paroxetine Triggers Inflammatory State on Zebrafish Early Embryonic Development.Life (Basel, Switzerland) · 2025Article
- Longitudinal pathways between parent depression and child mental health in families of autistic children.Development and psychopathology · 2025Article
- Utilising Behavioural and Sensory Profiles and Associated Perinatal Factors to Identify Meaningful Subgroups in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2025Article
- Parental stress, mental health, and child traits in Italian mothers and fathers of autistic children.Frontiers in psychology · 2025Article
- Family history of psychiatric conditions and development of siblings of children with autism.Autism research : official journal of the International Society for Autism Research · 2024Article
- Frontal EEG alpha asymmetry in youth with autism: Sex differences and social-emotional correlates.Autism research : official journal of the International Society for Autism Research · 2023Article
- Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program.Autism research : official journal of the International Society for Autism Research · 2023Article
- The intersection of genome, epigenome and social experience in autism spectrum disorder: Exploring modifiable pathways for intervention.Neurobiology of learning and memory · 2023Article
- Parental Depression Symptoms and Internalizing Mental Health Problems in Autistic Children.Journal of autism and developmental disorders · 2023Article
- Article
- Anxiety and depression in parents of children with autism spectrum disorder during the first COVID-19 lockdown: Report from the ELENA cohort.Journal of psychiatric research · 2022Observational
- Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants.Communications medicine · 2022Article
- Autism severity aggregates with family psychiatric history in a community-based autism sample.Autism research : official journal of the International Society for Autism Research · 2021Article
- Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.Biological psychiatry · 2021Article
- Therapeutic Alliance in Cognitive Behavioural Therapy in Child and Adolescent Mental Health-Current Trends and Future Challenges.Frontiers in psychology · 2021Article
- Early postnatal maternal trait anxiety is associated with the behavioural outcomes of children born preterm <33 weeks.Journal of psychiatric research · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
This study explored whether ASD phenotypes in the child were associated with a history of anxiety or depression in the mother. We hypothesized that an ASD profile in children characterized by mild delays and increased rates of dysregulation would be associated with preexisting maternal anxiety or depression. Participants were 672 preschool children with ASD and their mothers. Children were classified as ASD after a comprehensive developmental evaluation. Mothers reported whether a healthcare provider ever diagnosed them with anxiety or depression before the birth of their child. Four child ASD phenotypes were derived from latent class analysis: Mild Language Delay with Cognitive Rigidity (Type 1), Significant Developmental Delay with Repetitive Motor Behaviors (Type 2), General Developmental Delay (Type 3), and Mild Language and Motor Delay with Dysregulation (i.e., aggression, anxiety, depression, emotional reactivity, inattention, somatic complaints, and sleep problems) (Type 4). Type 2 ASD served as the referent category in statistical analyses. Results showed that 22.6% of mothers reported a diagnosis of anxiety or depression before the birth of their child. Maternal anxiety or depression was associated with 2.7 times the odds (95% confidence interval: 1.4, 5.3) of Type 4 or Dysregulated ASD in the child; maternal anxiety and depression was associated with 4.4 times the odds (95% confidence interval: 1.4, 14.0) of Type 4 or Dysregulated ASD in the child. Our findings suggest an association between Dysregulated ASD in the child and anxiety and depression in the mother. These findings can enhance screening methods and inform future research efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.