ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2018
Heart rate variability in Parkinson disease and idiopathic REM sleep behavior disorder.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03775096 (The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease), which is not on this map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Cardiac 123I-Meta-Iodobenzylguanidine Imaging as a Biomarker for Body-First Parkinson's Disease: Linking Peripheral α-Synuclein to Clinical Subtyping.Journal of movement disorders · 2026Article
- Heart rate variability impairment during sleep in Veterans with rapid eye movement sleep behaviour disorder, traumatic brain injury, and post-traumatic stress disorder: an early potential window into autonomic dysfunction?Journal of sleep research · 2025Article
- Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy.European journal of neurology · 2025Article
- Digital biomarkers for non-motor symptoms in Parkinson's disease: the state of the art.NPJ digital medicine · 2024Review
- A diagnostic model for Parkinson's disease based on circadian rhythm-related genes.Journal of translational medicine · 2024Article
- Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder.IEEE open journal of engineering in medicine and biology · 2024Article
- Genetic associations between Rapid Eye Movement (REM) sleep behavior disorder and cardiovascular diseases.PloS one · 2024Article
- Externally validated deep learning model to identify prodromal Parkinson's disease from electrocardiogram.Scientific reports · 2023Article
- Heart rate variability during sleep in synucleinopathies: a review.Frontiers in neurology · 2023Review
- Early onset of sleep/wake disturbances in a progressive macaque model of Parkinson's disease.Scientific reports · 2022Article
- Dysautonomia in Parkinson's Disease: Impact of Glucocerebrosidase Gene Mutations on Cardiovascular Autonomic Control.Frontiers in neuroscience · 2022Article
- Short-term deceleration capacity of heart rate: a sensitive marker of cardiac autonomic dysfunction in idiopathic Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Proof of concept: Screening for REM sleep behaviour disorder with a minimal set of sensors.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Autonomic impairment in REM sleep behavior disorder: a potential biomarker of phenoconversion?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson's Disease.Parkinson's disease · 2020Article
- Autonomic dysfunction in sleep disorders: introduction to the series.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Article
- Empatica E4 wristband assessment of probable REM sleep behavior disorder in people with Parkinson's disease. Results from the DIGI.PARK study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHeart rate variability, a marker of autonomic function modulation, is known to be blunted in Parkinson disease, although data remains conflicting and a putative modifying role of REM sleep behavior disorder persists unclarified.
methodsWe assessed ten patients with idiopathic REM sleep behavior disorder patients, 18 patients with Parkinson disease and REM behavior disorder and eight patients with Parkinson disease without REM sleep behavior disorder. Heart rate variability analysis was performed in 5-min epochs selected from wake, Non-REM and REM polysomnography records. We compared heart rate variability measures by stage between two sets of groups: Parkinson disease vs. idiopathic RBD and patients with vs. without RBD, by using repeated measures ANOVA.
resultsThere were no heart rate variability differences between Parkinson disease and idiopathic REM sleep behavior disorder groups. There were significant stage vs. group interactions (p = 0.045) regarding the high frequencies components when comparing patients with and without REM sleep behavior disorder, with the former presenting lower values and attenuation of sleep stage variations.
conclusionOur study suggests that RBD is related with reduction in parasympathetic modulation of heart rate variability and blunting of sleep stage related variations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.