ArticleBrain imaging and behavior2019
Regional leukoaraiosis and cognition in non-demented older adults.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Changes in Cognitive Function After Kidney Transplantation: A Longitudinal Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Mediating roles of leukoaraiosis and infarcts in the effects of unilateral carotid artery stenosis on cognition.Frontiers in aging neuroscience · 2022Article
- Periventricular and deep abnormal white matter differ in associations with cognitive performance at midlife.Neuropsychology · 2021Article
- Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.Journal of Parkinson's disease · 2021Article
- Reaction Time Decomposition as a Tool to Study Subcortical Ischemic Vascular Cognitive Impairment.Journal of Alzheimer's disease reports · 2021Article
- Common neurodegenerative disorders in the perioperative setting: Recommendations for screening from the Society for Perioperative Assessment and Quality Improvement (SPAQI).Perioperative care and operating room management · 2020Article
- Pilot Investigation: Older Adults With Atrial Fibrillation Demonstrate Greater Brain Leukoaraiosis in Infracortical and Deep Regions Relative to Non-Atrial Fibrillation Peers.Frontiers in aging neuroscience · 2020Article
- Abnormal Interactions of the Salience Network, Central Executive Network, and Default-Mode Network in Patients With Different Cognitive Impairment Loads Caused by Leukoaraiosis.Frontiers in neural circuits · 2019Article
- Reaction Time and Visible White Matter Lesions in Subcortical Ischemic Vascular Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Article
- Subcortical Ischemic Vascular Cognitive Impairment: Insights from Reaction Time Measures.Journal of Alzheimer's disease : JAD · 2019Article
- Neuropsychological impact of white matter hyperintensities in older adults without dementia.Applied neuropsychology. AdultArticle
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Frontal lobe-executive functions are heavily dependent on distal white matter connectivity. Even with healthy aging there is an increase in leukoaraiosis that might interrupt this connectivity. The goal of this study is to learn 1) the location, depth, and percentage of leukoaraiosis in white matter among a sample of non-demented older adults and 2) associations between these leukoarioasis metrics and composites of cognitive efficiency (processing speed, working memory, and inhibitory function), and episodic memory. Participants were 154 non-demented older adults (age range 60-85) who completed a brain MRI and neuropsychological testing on the same day. Brain MRIs were segmented via Freesurfer and white matter leukoaraiosis depth segmentations was based on published criteria. On average, leukoaraiosis occupied 1 % of total white matter. There was no difference in LA distribution in the frontal (1.12%), parietal (1.10%), and occipital (0.95%) lobes; there was less LA load within the temporal lobe (0.23%). For cortical depth, leukoaraiosis was predominantly in the periventricular region (3.39%; deep 1.46%, infracortical 0.15%). Only increasing frontal lobe and periventricular leukoaraiosis were associated with a reduction in processing speed, working memory, and inhibitory function. Despite the general presence of LA throughout the brain, only frontal and periventricular LA contributed to the speeded and mental manipulation of executive functioning. This study provides a normative description of LA for non-demented adults to use as a comparison to more disease samples.
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