Evidence map›Paper›PMID 30128298›Full record

ArticleToxicology reports2018

Acute toxicity studies of the South African medicinal plant

Tiza Ng'uni, Jeremy A Klaasen, Burtram C Fielding

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2026
    Article
  2. TiACS applied materials & interfaces · 2026
    Article
  3. Phenolic-Rich Extracts ofPlants (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Evaluation of Dermal Toxicity and Wound Healing Activity ofAdvances in pharmacological and pharmaceutical sciences · 2022
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Chemical profile andToxicology reports · 2019
    Article
  12. Toxicity study onToxicology reports · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tiza Ng'uniMolecular Biology and Virology Laboratory, Department of Medical BioSciences, Faculty of Natural Sciences, University of the Western Cape, Western Cape, South Africa.
Jeremy A KlaasenPlant Extract Laboratory, Department of Medical BioSciences, Faculty of Natural Sciences, University of the Western Cape, Western Cape, South Africa.
Burtram C FieldingMolecular Biology and Virology Laboratory, Department of Medical BioSciences, Faculty of Natural Sciences, University of the Western Cape, Western Cape, South Africa.
University of the Western Cape · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMedicinal plants are used by a large proportion of the global population as complementary and alternative medicines. However, little is known about their toxicity.

methodsThe acute oral and dermal toxicity potential of

resultsThe results of the acute oral and dermal toxicity studies revealed that the median lethal dosage (LD

conclusionThese findings demonstrate that the acute toxicity profile for

Indexed as

Acute toxicityDermal sensitizationDPM, disintegrations per minuteECVAM, European Centre for the Validation of Alternative Methods (ECVAM)EpiskinG. africana, Galenia africanaGalenia africanaGHS, globally harmonized aystemGLP, good laboratory practiceHCA, hexylcinnamicaldehydeLD50, lethal oral dosageLLNA, local lymph node assayLocal lymph node assayMTT, methylthiazoldiphenyl-tetrazolium bromide (MTT)NAD, no abnormalities detectedOECD, Organization for Economic Co-operation and DevelopmentPBS, phosphate buffered salineSI, stimulation indexSkin irritationWHO, World Health Organization

Identifiers

PMID30128298
PMCPMC6098221
OpenAlexW2886987891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.