ArticleNeuroImage. Clinical2018
The correlation of asymmetrical functional connectivity with cognition and reperfusion in carotid stenosis patients.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation.Neural plasticity · 2020Trial
- Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting.Translational stroke research · 2025Article
- Carotid revascularization improves cognition in patients with carotid stenosis.Scientific reports · 2025Article
- Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease.Frontiers in aging neuroscience · 2025Article
- Cortical structural network characteristics in non-cognitive impairment end-stage renal disease.Frontiers in neuroscience · 2024Article
- Alterations in brain morphology and functional connectivity mediate cognitive decline in carotid atherosclerotic stenosis.Frontiers in aging neuroscience · 2024Article
- Changes in Cognitive Functions after Carotid Endarterectomy and Carotid Stenting: A Decade-Apart Comparison.Biomedicines · 2023Article
- Review
- Neuroimaging anomalies in asymptomatic middle cerebral artery steno-occlusive disease with normal-appearing white matter.Frontiers in neurology · 2023Article
- Cognitive functions and sense of coherence in patients with carotid artery stenosis-Preliminary report.Frontiers in psychiatry · 2023Article
- Cognitive Functions after Carotid Artery Stenting-1-Year Follow-Up Study.Journal of clinical medicine · 2022Article
- Functional MRI evaluation of cognitive effects of carotid stenosis revascularization.Brain and behavior · 2022Review
- Mediating roles of leukoaraiosis and infarcts in the effects of unilateral carotid artery stenosis on cognition.Frontiers in aging neuroscience · 2022Article
- Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks.Frontiers in aging neuroscience · 2022Article
- Brain alterations of regional homogeneity, degree centrality, and functional connectivity in vulnerable carotid plaque patients with neither clinical symptoms nor routine MRI lesions: A resting-state fMRI study.Frontiers in neuroscience · 2022Article
- Cognitive Functions in Patients after Carotid Artery Revascularization-A Narrative Review.Brain sciences · 2021Review
- Association between metabolic syndrome and resting-state functional brain connectivity.Neurobiology of aging · 2021Article
- Cognitive Sequelae of Silent Ischemic Lesions Following Carotid Artery Stenting: Possible Role of Age-Related Moderation.Frontiers in aging neuroscience · 2021Article
- Neurodegeneration and Vascular Burden on Cognition After Midlife: A Plasma and Neuroimaging Biomarker Study.Frontiers in human neuroscience · 2021Article
- Changes of Brain Functional Connectivity in End-Stage Renal Disease Patients Receiving Peritoneal Dialysis Without Cognitive Decline.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Neural disruption and cognitive impairment have been reported in patients with carotid stenosis (CS), but carotid artery stenting (CAS) may not contribute to the cognitive recovery. Although functional hyper-connectivity is one of the physiological over-compensation phenomena in neurological diseases, the literature on the cognitive influence of functional hyper-connectivity in CS patients is limited. We aimed to investigate the longitudinal changes of hyper-connectivity after CAS and its association with cognition in CS patients. Methods: Thirteen patients with unilateral CS and 17 controls without CS were included. Cognitive function was evaluated at baseline, and resting-state functional MRI was performed 1 week before and 1 month and 1 year after CAS. Comparisons of functional connectivity (FC) between CS patients and controls in multiple brain networks were performed. Results: In patients before CAS, FC in the cerebral hemispheres ipsilateral and contralateral to CS was mainly decreased and increased, respectively, compared with normal controls. Part of the FC alterations gradually recovered to the normal condition after CAS. The stronger FC abnormality (both hypo- and hyper-connectivity compared with normal controls) was associated with poorer cognitive performances, especially in memory and executive functions. Conclusion: The study demonstrated the lateralization of hyper-connectivity and hypo-connectivity in patients with unilateral CS in contrast to the FC in normal controls. These FC alterations were associated with poor cognitive performances and tended to recover after CAS, implying that hyper-connectivity is served as a compensation for neural challenge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.