Evidence map›Paper›PMID 30128229›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2018

Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration.

Yiwa Pan, Junyao Yang, Yongzhen Wei, He Wang, Rongkuan Jiao, Ana Moraga, Zhongyi Zhang, Yanhua Hu, Deling Kong, Qingbo Xu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

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  15. Histone Deacetylase 7-Derived Peptides Play a Vital Role in Vascular Repair and Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Yiwa PanState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
Junyao YangCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Yongzhen WeiState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
He WangState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
Rongkuan JiaoState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
Ana MoragaCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Zhongyi ZhangCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Yanhua HuCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Deling KongState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
Qingbo XuCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Lingfang ZengCardiovascular Division Faculty of Life Science and Medicine King's College London London SE5 9NU UK.
Qiang ZhaoState key Laboratory of Medicinal Chemical Biology and Key Laboratory of Bioactive Materials (Ministry of Education) College of Life Sciences Nankai University Tianjin 300071 P. R. China.
Faculty (United Kingdom) · GBKing's College London · GBNankai University · CNState Key Laboratory of Medicinal Chemical BiologyJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is a leading cause of morbidity and mortality globally. Accumulating evidence indicates that local resident stem/progenitor cells play an important role in vascular regeneration. Recently, it is demonstrated that a histone deacetylase 7-derived 7-amino acid peptide (7A, MHSPGAD) is critical in modulating the mobilization and orientated differentiation of these stem/progenitor cells. Here, its therapeutic efficacy in vascular repair and regeneration is evaluated. In vitro functional analyses reveal that the 7A peptide, in particular phosphorylated 7A (7Ap, MH[pSer]PGAD), could increase stem cell antigen-1 positive (Sca1

Indexed as

HDAC7‐derived peptideischaemia diseasetissue‐engineered vascular grafts (TEVGs)vascular progenitor cells (VPCs)

Identifiers

PMID30128229
PMCPMC6097091
OpenAlexW2809776043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.