ArticleAllergy & rhinology (Providence, R.I.)
Determinants of the Nasal Microbiome: Pilot Study of Effects of Intranasal Medication Use.
Article in Allergy & rhinology (Providence, R.I.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Effects of Corticosteroids on the Respiratory Microbiome: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Towards airway microbiome engineering for improving respiratory health.Advanced drug delivery reviews · 2025Review
- Characteristics of healthy sinonasal microbiome - single-centre study in the Czech Republic.Journal of applied biomedicine · 2025Article
- Airway microbial and metabolic features associated with ICS therapy in COPD.Frontiers in pharmacology · 2025Article
- Clinical and Microbial Determinants of Upper Respiratory Colonization With Streptococcus pneumoniae and Native Microbiota in People With Human Immunodeficiency Virus Type 1 and Control Adults.The Journal of infectious diseases · 2024Article
- Associations of Microbial Diversity with Age and Other Clinical Variables among Pediatric Chronic Rhinosinusitis (CRS) Patients.Microorganisms · 2023Article
- The nasal microbiome in patients suffering from non-steroidal anti-inflammatory drugs-exacerbated respiratory disease in absence of corticosteroids.Frontiers in immunology · 2023Article
- Nasal microbiome disruption and recovery after mupirocin treatment in Staphylococcus aureus carriers and noncarriers.Scientific reports · 2022Article
- Inhaled Corticosteroids and the Lung Microbiome in COPD.Biomedicines · 2021Review
- Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose.Cell reports · 2021Article
- The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease.Medicina (Kaunas, Lithuania) · 2021Review
- The Role of Upper Airway Microbiome in the Development of Adult Asthma.Immune network · 2021Review
- Article
- Influence of the Microbiome on Chronic Rhinosinusitis With and Without Polyps: An Evolving Discussion.Frontiers in allergy · 2021Review
- COVID-19 and upper respiratory tract: Collecting swab specimens from patients inhaling corticosteroids.The Journal of allergy and clinical immunology · 2020Article
- The microbiome of the upper respiratory tract in health and disease.BMC biology · 2019Review
- Microbiome and disease in the upper airway.Current opinion in allergy and clinical immunology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA role for bacteria and other microbes has long been suspected in the chronic inflammatory sinonasal diseases. Recent studies utilizing culture-independent, sequence-based identification have demonstrated aberrant shifts in the sinus microbiota of chronic rhinosinusitis subjects, compared with ostensibly healthy controls. Examining how such microbiota shifts occur and the potential for physician-prescribed interventions to influence microbiota dynamics are the topics of the current article.
methodsThe nasal cavity microbiota of 5 subjects was serially examined over an 8-week period using pan-bacterial 16S rRNA gene sequencing. Four of the subjects were administered topical mometasone furoate spray, while 1 subject underwent a mupirocin decolonization procedure in anticipation of orthopedic surgery.
resultsMeasures of microbial diversity were unaffected by intranasal treatment in 2 patients and were markedly increased in the remaining 3. The increase in microbial diversity was related to clearance of
conclusionsThe effects of intranasal steroids on the sinonasal microbiome are poorly understood, despite their widespread use in treating chronic sinonasal inflammatory disorders. In this longitudinal study, administration of intranasal mometasone furoate or mupirocin resulted in shifts in microbial diversity that persisted to some degree following treatment cessation. Further characterization of these effects as well as elucidation of the mechanism(s) underlying these changes is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.