Evidence map›Paper›PMID 30128049›Full record

ArticleTheranostics2018

Nerve-targeted probes for fluorescence-guided intraoperative imaging.

Dina V Hingorani, Michael A Whitney, Beth Friedman, Joong-Keun Kwon, Jessica L Crisp, Qing Xiong, Larry Gross, Christopher J Kane, Roger Y Tsien, Quyen T Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. [Near-infrared targeted probe designed for intraoperative imaging of prostatic neurovascular bundles].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dina V HingoraniDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California at San Diego, La Jolla, California, USA.
Michael A WhitneyDepartment of Pharmacology, University of California at San Diego, La Jolla, California, USA.
Beth FriedmanDepartment of Pharmacology, University of California at San Diego, La Jolla, California, USA.
Joong-Keun KwonDepartment of Otorhinolaryngology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.
Jessica L CrispHoward Hughes Medical Institute, University of California at San Diego, La Jolla, California, USA.
Qing XiongHoward Hughes Medical Institute, University of California at San Diego, La Jolla, California, USA.
Larry GrossHoward Hughes Medical Institute, University of California at San Diego, La Jolla, California, USA.
Christopher J KaneDepartment of Urology, UC San Diego Health System, La Jolla, California, USA.
Roger Y TsienDepartment of Pharmacology, University of California at San Diego, La Jolla, California, USA.
Quyen T NguyenDepartment of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California at San Diego, La Jolla, California, USA.

Funding

Testing Fluorescently Labeled Probes for Nerve Imaging during SurgeryR01EB014929 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2012 to 2016
$1.7M
Development of Human-Selective Nerve Illumination Peptide for SurgeryR56EB025910 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2018 to 2019
$299k
NIBIB NIH HHS R01 EB014929NIBIB NIH HHS R56 EB025910
6 · The paper itself

Abstract

A fundamental goal of many surgeries is nerve preservation, as inadvertent injury can lead to patient morbidity including numbness, pain, localized paralysis and incontinence. Nerve identification during surgery relies on multiple parameters including anatomy, texture, color and relationship to surrounding structures using white light illumination. We propose that fluorescent labeling of nerves can enhance the contrast between nerves and adjacent tissue during surgery which may lead to improved outcomes.

Indexed as

Administration, IntravenousAnimalsFluorescent DyesHumansMiceMolecular ImagingNeuroimagingOptical ImagingPeptidesProtein BindingRatsStaining and LabelingSurgery, Computer-AssistedFluorescent DyesPeptidesfluorescence imaginghuman nervenerve targetingtranslational

Identifiers

PMID30128049
PMCPMC6096382

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.