Evidence map›Paper›PMID 30128018›Full record

ArticleOncology letters2018

Silencing of uPAR via RNA interference inhibits invasion and migration of oral tongue squamous cell carcinoma.

Xuexiang Gao, Qi Guo, Shuo Wang, Cen Gao, Jian Chen, Li Zhang, Yuan Zhao, Jing Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xuexiang GaoSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Qi GuoSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Shuo WangSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Cen GaoSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Jian ChenDepartment of Pediatric Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Li ZhangSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Yuan ZhaoSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Jing WangSchool of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Lanzhou University · CNFirst Hospital of Lanzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of urokinase-type plasminogen activator receptor (uPAR) has been implicated in promoting tumor invasion in various cancer types, including oral tongue squamous cell carcinoma (OTSCC); therefore, the effect of suppressing uPAR expression on the invasive and metastatic potential of OTSCC was investigated. A total of 65 paraffin-embedded tissues were obtained from patients with OTSCC. Immunohistochemistry was used to determine the expression level of uPAR. The Ts cells transfected with short hairpin RNA targeting uPAR were constructed and validated. The cells were used in a number of

Indexed as

invasionmigrationoral tongue squamous cell carcinomaRNA interferenceurokinase-type plasminogen activator receptor

Identifiers

PMID30128018
PMCPMC6096076
OpenAlexW2878649898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.