ArticleOncology letters2018
Suppression of Hiwi inhibits the growth and epithelial-mesenchymal transition of cervical cancer cells.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2024Article
- Targeting Cervical Cancer Stem Cells by Phytochemicals.Current medicinal chemistry · 2024Review
- Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis.Biomedicines · 2022Article
- PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy.Human cell · 2021Review
- Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells.American journal of physiology. Lung cellular and molecular physiology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer is a common gynecological malignancy. Hiwi exhibits a high level of expression in cervical cancer cells. However, the effects of Hiwi expression in cervical cancer cells remain unresolved. In the present study, the effects of Hiwi downregulation on the growth and epithelial-mesenchymal transition of cervical cancer cells were investigated. The results of the present study revealed that the suppression of Hiwi was able to inhibit the proliferation of cervical cancer cells and arrest cell cycle at G1 phase. The downregulation of Hiwi was also revealed to inhibit the epithelial-mesenchymal transition process of cervical cancer cells by regulating the expression of E-cadherin, N-cadherin, vimentin, and snail. The present study demonstrated that the suppression of Hiwi was able to inhibit the growth and epithelial-mesenchymal transition of cervical cancer cells. Therefore, the results suggest that Hiwi may function as an oncogene in cervical cancer cells and may become a potential target for cervical cancer therapy.
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Registered trials
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