Evidence map›Paper›PMID 30127986›Full record

ArticleOncology letters2018

Novel formulations of docetaxel, paclitaxel and doxorubicin in the management of metastatic breast cancer.

Senthil Rajappa, Ashish Joshi, Dinesh C Doval, Ullas Batra, Rejiv Rajendranath, Avinash Deo, Ghanshyam Biswas, Peush Bajpai, T V S Tilak, Sriram Kane and 9 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Treatment with nanosomal paclitaxel lipid suspensionTherapeutic advances in medical oncology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 1 country.

Senthil RajappaDepartment of Medical Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, Telangana 500034, India.
Ashish JoshiNanavati Hospital, Mumbai, Maharashtra 400056, India.
Dinesh C DovalRajiv Gandhi Cancer Institute and Research Centre, Delhi 110085, India.
Ullas BatraRajiv Gandhi Cancer Institute and Research Centre, Delhi 110085, India.
Rejiv RajendranathApollo Speciality Hospital, Chennai, Tamil Nadu 600096, India.
Avinash DeoFortis SL Raheja Hospital, Mumbai, Maharashtra 400016, India.
Ghanshyam BiswasSparsh Hospital, Bhubaneswar, Odisha 751007, India.
Peush BajpaiMax Super Speciality Hospital, New Delhi 110017, India.
T V S TilakCommand Hospital, Bangalore, Karnataka 560007, India.
Sriram KaneKane Hematology and Oncology Clinic, Nagpur, Maharashtra 440012, India.
Kishore KumarCommand Hospital, Bangalore, Karnataka 560007, India.
Manish KumarCommand Hospital, Lucknow, Uttar Pradesh 226002, India.
Avinash D TaleleCHL Hospital, Indore, Madhya Pradesh 452008, India.
Prakash DevdeSeth Nandlal Dhoot Hospital, Aurangabad, Maharashtra 431210, India.
Ashutosh GuptaGovernment Medical College, Jammu, Jammu and Kashmir 180001, India.
Nisarg JoshiIntas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380061, India.
Jaykumar SejpalIntas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380061, India.
Deepak BungerIntas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380061, India.
Mujtaba KhanIntas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380061, India.
Intas Pharmaceuticals (India) · INCommand Hospital · INRajiv Gandhi Cancer Institute and Research Centre · INApollo Hospitals · INBasavatarakam Indo American Cancer Hospital and Research Institute · INDr. Balabhai Nanavati Hospital · INGovernment Medical College · INMaharaja Yeshwantrao Hospital · INMax Super Speciality Hospital · INSeth Nandlal Dhoot Hospital · INS.L. Raheja Hospital · INSparsh Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of breast cancer with advanced disease or metastasis is a common problem in India and other countries. A panel of 13 oncology experts deliberated on the sidelines of the 35th Indian Cooperative Oncology Network Conference held in Mumbai to formulate an expert opinion recommendation on the novel drug delivery system (NDDS) formulations in the treatment of metastatic breast cancer (MBC). The survey comprised of 39 questions related to limitations of conventional formulations and therapeutic positioning of NDDS formulations of docetaxel, paclitaxel and doxorubicin in the management of MBC. The experts used data from published literature and their practical experience to provide expert opinion and recommendations for use by the community oncologists. The experts opined that the newer NDDS formulations should provide a significant efficacy advantage in terms of overall survival and progression-free survival, or demonstrate better tolerability when compared with conventional formulations. The newer NDDS formulations of taxanes should be considered in special circumstances such as diabetes, in patients who have had hypersensitivity reactions and in cases where steroids need to be avoided. The novel formulations of doxorubicin should be used in the elderly and in patients with borderline cardiac function.

Indexed as

doceaqualipexperts' opinionmetastatic breast cancernovel drug delivery systempacliaqualippegylated liposomal doxorubicin

Identifiers

PMID30127986
PMCPMC6096158
OpenAlexW2811437945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.