Evidence map›Paper›PMID 30127933›Full record

ArticleOncology letters2018

Arsenic trioxide and sorafenib combination therapy for human hepatocellular carcinoma functions via up-regulation of TNF-related apoptosis-inducing ligand.

Lingyan Wang, Zhihui Min, Xiangdong Wang, Mushuang Hu, Dongli Song, Zhenggang Ren, Yunfeng Cheng, Yanhong Wang

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. [Liver cancer treatment with mitochondrial homeostasis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lingyan WangInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Zhihui MinInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Xiangdong WangInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Mushuang HuInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Dongli SongInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Zhenggang RenLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Yunfeng ChengInstitute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Yanhong WangLiver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
Fudan University · CNZhongshan Hospital · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The survival benefits of sorafenib treatment for patients with hepatocellular carcinoma (HCC) are limited due to drug resistance and side effects. Therefore, combinations of sorafenib with other low toxicity drugs, including arsenic trioxide (As

Indexed as

apoptosisAs2O3human hepatocellular carcinomasorafenibTNF-related apoptosis-inducing ligand

Identifiers

PMID30127933
PMCPMC6096064
OpenAlexW2809227740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.