ArticleOncology letters2018
Anti-Condyloma acuminata mechanism of microRNAs-375 modulates HPV in cervical cancer cells via the UBE3A and IGF-1R pathway.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA.Current medicinal chemistry · 2025Pooled it
- Effects of UBE3A on the insulin resistance in polycystic ovary syndrome through the ubiquitination of AMPK.BMC endocrine disorders · 2023Article
- Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer.Cancers · 2021Review
- Article
- The Role of microRNAs, Long Non-coding RNAs, and Circular RNAs in Cervical Cancer.Frontiers in oncology · 2020Review
- The Reciprocal Interaction Between LncRNA CCAT1 and miR-375-3p Contribute to the Downregulation of IRF5 Gene Expression by Solasonine in HepG2 Human Hepatocellular Carcinoma Cells.Frontiers in oncology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly increased caspase-3 and caspase-9 activities, induced B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein, tumor protein 53 and cyclin-dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly suppressed the levels of protein expression of ubiquitin-protein ligase E3A (UBE3A) and Insulin-like growth factor-1 receptor (IGF-1R) in HPV-18(+) cervical cancer cells. To conclude, it was identified that the probable anti-CA mechanism of miRNA-375 modulates HPV through the UBE3A and IGF-1R pathway in cervical cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.