ArticleIranian journal of pharmaceutical research : IJPR2018
Embryo-Protective Effects of Cerium Oxide Nanoparticles against Gestational Diabetes in Mice.
Article in Iranian journal of pharmaceutical research : IJPR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases.Journal of advanced research · 2025Pooled it
- Ameliorative effect of curcumin and/or cerium oxide nanoparticles on diabetes of rats: biochemical, molecular, and pathological insights.Scientific reports · 2026Article
- Mechanistic paradigms of teratogenicity induced by metallic nanoparticles-a mini review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Biodistribution and Toxicological Impact Assessment of Cerium Dioxide Nanoparticles in Murine Models: A Systematic Review of In Vivo and Ex Vivo Studies.Pharmaceutics · 2025Review
- Pharmacological Action of Baicalin on Gestational Diabetes Mellitus in Pregnant Animals Induced by Streptozotocin via AGE-RAGE Signaling Pathway.Applied biochemistry and biotechnology · 2024Article
- Nanotechnologies in Obstetrics and Cancer during Pregnancy: A Narrative Review.Journal of personalized medicine · 2022Review
- A Review of Nanotechnology for Treating Dysfunctional Placenta.Frontiers in bioengineering and biotechnology · 2022Review
- On Placental Toxicology Studies and Cerium Dioxide Nanoparticles.International journal of molecular sciences · 2021Review
- Targeted drug delivery for maternal and perinatal health: Challenges and opportunities.Advanced drug delivery reviews · 2021Review
- Detrimental effects of cerium oxide nanoparticles on testis, sperm parameters quality, and in vitro fertilization in mice: An experimental study.International journal of reproductive biomedicine · 2021Article
- Investigation of therapeutic potential of cerium oxide nanoparticles in Alzheimer's disease using transgenic3 Biotech · 2021Article
- Diseases and conditions that impact maternal and fetal health and the potential for nanomedicine therapies.Advanced drug delivery reviews · 2021Review
- Early Pregnancy Exposure to Rare Earth Elements and Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study.Frontiers in endocrinology · 2021Article
- The preparation temperature influences the physicochemical nature and activity of nanoceria.Beilstein journal of nanotechnology · 2021Article
- The challenge of using nanotherapy during pregnancy: Technological aspects and biomedical implications.Placenta · 2020Review
- A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice.Oxidative medicine and cellular longevity · 2020Article
- Synthesis and biomedical applications of nanoceria, a redox active nanoparticle.Journal of nanobiotechnology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Diabetes during pregnancy increases the incidences of congenital anomalies, in a mother and her embryo. Oxidative stress has been implicated to be responsible in diabetic embryopathy. In this study, we used nanoceria as an antioxidant for amelioration of diabetic embryopathy in diabetic mice. The female mice were divided into 5 groups (6 mice per group). Diabetes was induced by a single dose of streptozotocin (60 mg/kg IP) that dissolved in citrate buffer (pH = 4.6). Blood glucose was checked in 0,5,10, and 15 days of pregnancy. The diabetic state was confirmed when the blood glucose concentration exceeded 200 mg/dL. On the day 16 of pregnancy, all animals were anesthetized with ether and embryos were excised; then oxidative stress, pathological parameters, number of implantations, miscarriage, and live embryo were assayed. Histological study showed that diabetes induced abortion; decrease in weight of mothers, embryo, and the number of embryos were observed. In diabetic mice, significant increase in lipid peroxidation (LPO), ROS formation, and protein carbonyl content were observed. Glutathione (GSH) concentration is found to be decreased in embryo tissue in diabetic mice. Nanoceria treatment significantly inhibited embryonic oxidative stress and also pathologic changes in diabetic mice. Our research showed that diabetes act as a teratogen agent for fetal development and nanoceria abrogated diabetes induced embryopathy via its antioxidant effects. So, early detection of diabetes in pregnancy and antioxidant administration can attenuate these complications.
Indexed as
Identifiers
30127819PMC6094439W2803045893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.