ArticleFrontiers in neurology2018
Utilizing a Structural Mechanics Approach to Assess the Primary Effects of Injury Loads Onto the Axon and Its Components.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A statistical damage model for coupled mechano-electrophysiological axonal injury.PLoS computational biology · 2026Article
- A model of axonal damage accumulation from real-world head impact exposure.Annals of biomedical engineering · 2026Article
- High-order mesoscale modeling with geometrically conforming gray/white matter interface for traumatic brain injury.Computer methods and programs in biomedicine · 2025Article
- Feedback-Driven Dynamical Model for Axonal Extension on Parallel Micropatterns.Biomimetics (Basel, Switzerland) · 2025Article
- Multiscale Computational and Artificial Intelligence Models of Linear and Nonlinear Composites: A Review.Small science · 2024Article
- Image-based axon model highlights heterogeneity in initiation of damage.Biophysical journal · 2023Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- A Brief Review of In Vitro Models for Injury and Regeneration in the Peripheral Nervous System.International journal of molecular sciences · 2022Review
- Viscoelastic damage evaluation of the axon.Frontiers in bioengineering and biotechnology · 2022Article
- Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury.Journal of neurotrauma · 2021Review
- Investigation of the Compressive Viscoelastic Properties of Brain Tissue Under Time and Frequency Dependent Loading Conditions.Annals of biomedical engineering · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier.Frontiers in molecular biosciences · 2021Article
- Mechanosensation in traumatic brain injury.Neurobiology of disease · 2021Review
- In vivo estimates of axonal stretch and 3D brain deformation during mild head impact.Brain multiphysics · 2020Article
- A network-based response feature matrix as a brain injury metric.Biomechanics and modeling in mechanobiology · 2020Article
- Localized Axolemma Deformations Suggest Mechanoporation as Axonal Injury Trigger.Frontiers in neurology · 2020Article
- Myelin Damage in Diffuse Axonal Injury.Frontiers in neuroscience · 2019Article
- A Precise, ControllableFrontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Diffuse axonal injury (DAI) occurs as a result of the transmission of rapid dynamic loads from the head to the brain and specifically to its neurons. Despite being one of the most common and most deleterious types of traumatic brain injury (TBI), the inherent cell injury mechanism is yet to be understood. Experimental observations have led to the formulation of different hypotheses, such as mechanoporation of the axolemma and microtubules (MTs) breakage. With the goal of singling out the mechanical aspect of DAI and to resolve the ambiguity behind its injury mechanism, a composite finite element (FE) model of a representative volume of an axon was developed. Once calibrated and validated against published experimental data, the axonal model was used to simulate injury scenarios. The resulting strain distributions along its components were then studied in dependence of strain rate and of typical modeling choices such as the applied MT constraints and tau proteins failure. Results show that oversimplifying the MT bundle kinematic entails a systematic attenuation (
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