Evidence map›Paper›PMID 30127749›Full record

ArticleFrontiers in physiology2018

Post-stroke Hemiplegic Gait: New Perspective and Insights.

Sheng Li, Gerard E Francisco, Ping Zhou

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 124 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 7 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06113965 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Neural Operant Conditioning to Improve Walking After Stroke

TypeinterventionalSponsorMetroHealth Medical CenterRan2024 to 2028Enrolled0ConditionsStroke, Chronic Stroke, Gait, Hemiplegic, Gait, SpasticArmsPeripheral Nerve Stimulation
NCT06500611 narecruitingnot on this mapstarted 2024, after this paper: background citation

Combined Effects Of Sensory Integration And Vestibular Exercises On Dizziness, Fall Risk And Quality Of Life In Post-Stroke Patients

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled38ConditionsPost StrokeArmsSensory Integration and Vestibular Exercise with Routine Physical Therapy, Vestibular Exercise with Routine Physical Therapy
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 7 syntheses or guidelines pooled it, 272 citations in OpenAlex.

  1. Pooled it
  2. Effects of transcutaneous spinal stimulation with gait training on walking-related outcomes in stroke survivors: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  3. Corticospinal Responses Following Gait-Specific Training in Stroke Survivors: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  8. Trial
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  19. Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026
    Review
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sheng LiDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, United States.
Gerard E FranciscoDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, United States.
Ping ZhouDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center, Houston, TX, United States.
Memorial Hermann Institute for Rehabilitation and Research Foundation · USThe University of Texas Health Science Center at Houston · US

Funding

Imaging of 3D Innervation Zone Distribution in Spastic Muscles from High-Density Surface EMG RecordingsR21HD090453 · NICHD · UNIVERSITY OF HOUSTON · PI LI, SHENG, ZHANG, YINGCHUN · 2017 to 2018
$434k
Breathing-controlled Electrical Stimulation for Phantom Pain ManagementR21HD087128 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, SHENG · 2016 to 2017
$424k
NICHD NIH HHS R21 HD087128NICHD NIH HHS R21 HD090453
6 · The paper itself

Abstract

Walking dysfunction occurs at a very high prevalence in stroke survivors. Human walking is a phenomenon often taken for granted, but it is mediated by complicated neural control mechanisms. The automatic process includes the brainstem descending pathways (RST and VST) and the intraspinal locomotor network. It is known that leg muscles are organized into modules to serve subtasks for body support, posture and locomotion. Major kinematic mechanisms are recognized to minimize the center of gravity (COG) displacement. Stroke leads to damage to motor cortices and their descending corticospinal tracts and subsequent muscle weakness. On the other hand, brainstem descending pathways and the intraspinal motor network are disinhibited and become hyperexcitable. Recent advances suggest that they mediate post-stroke spasticity and diffuse spastic synergistic activation. As a result of such changes, existing modules are simplified and merged, thus leading to poor body support and walking performance. The wide range and hierarchy of post-stroke hemiplegic gait impairments is a reflection of mechanical consequences of muscle weakness, spasticity, abnormal synergistic activation and their interactions. Given the role of brainstem descending pathways in body support and locomotion and post-stroke spasticity, a new perspective of understanding post-stroke hemiplegic gait is proposed. Its clinical implications for management of hemiplegic gait are discussed. Two cases are presented as clinical application examples.

Indexed as

botulinum toxingaithemiparesismotor recoveryspasticitystroke

Identifiers

PMID30127749
PMCPMC6088193
OpenAlexW2886482541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.