Evidence map›Paper›PMID 30127705›Full record

ArticleJournal of Korean medical science2018

Real-world Evidence versus Randomized Controlled Trial: Clinical Research Based on Electronic Medical Records.

Hun-Sung Kim, Suehyun Lee, Ju Han Kim

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07362407 (Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments), which is not on this map. Cited by 235 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07362407 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study (CANAREAL)

Typeobservational_patient_registrySponsorSanta Catarina Federal UniversityRan2026 to 2026Enrolled384ConditionsChronic Pain, Depression Disorders, Anxiety Disorders, Quality of LifeArmsParticipants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes.
3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  7. Second Primary Malignancies after CAR T-Cell Therapy: A Systematic Review and Meta-analysis of 5,517 Lymphoma and Myeloma Patients.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hun-Sung KimDepartment of Medical Informatics, The Catholic University of Korea College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7002-7300
Suehyun LeeDivision of Biomedical Informatics, Systems Biomedical Informatics Research Center, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-0651-6481
Ju Han KimDivision of Biomedical Informatics, Systems Biomedical Informatics Research Center, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1522-9038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-world evidence (RWE) and randomized control trial (RCT) data are considered mutually complementary. However, compared with RCT, the outcomes of RWE continue to be assigned lower credibility. It must be emphasized that RWE research is a real-world practice that does not need to be executed as RCT research for it to be reliable. The advantages and disadvantages of RWE must be discerned clearly, and then the proper protocol can be planned from the beginning of the research to secure as many samples as possible. Attention must be paid to privacy protection. Moreover, bias can be reduced meaningfully by reducing the number of dropouts through detailed and meticulous data quality management. RCT research, characterized as having the highest reliability, and RWE research, which reflects the actual clinical aspects, can have a mutually supplementary relationship. Indeed, once this is proven, the two could comprise the most powerful evidence-based research method in medicine.

Indexed as

Electronic Health RecordsBiasRandomized Controlled Trials as TopicReproducibility of ResultsResearch DesignRandomized Control TrialReal-world DataReal-world Evidence

Identifiers

PMID30127705
PMCPMC6097073

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.