Evidence map›Paper›PMID 30127668›Full record

ArticleClinical ethics2018

The Ethical Concerns of Seeking Consent from Critically Ill, Mechanically Ventilated Patients for Research - A Matter of Possessing Capacity or Surrogate Insight.

Avelino C Verceles, Waqas Bhatti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ethics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Avelino C VercelesDivision of Pulmonary, Critical Care & Sleep Medicine, University of Maryland School of Medicine, 110 S. Paca Street, Baltimore, MD 21201, USA.
Waqas BhattiDivision of Pulmonary, Critical Care & Sleep Medicine, University of Maryland School of Medicine, 110 S. Paca Street, Baltimore, MD 21201, USA.

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Rehabilitation, NMES and High Protein to Reduce Post ICU Syndrome in the ElderlyR21AG050890 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI VERCELES, AVELINO CATALINO · 2015 to 2016
$422k
The Multimodal Rehabilitation of Older Ventilated Survivors Of Critical IllnessR03AG045100 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI VERCELES, AVELINO CATALINO · 2013 to 2014
$154k
NIA NIH HHS P30 AG028747NIA NIH HHS R03 AG045100NIA NIH HHS R21 AG050890
6 · The paper itself

Abstract

Conducting clinical research on subjects admitted to intensive care units is challenging as they frequently lack the capacity to provide informed consent due to multiple factors including ICU acquired delirium, coma, the need for sedation, or underlying critical illness. However, the presence of one or more of these characteristics does not automatically designate a potential subject as lacking capacity to provide their own informed consent. We review the ethical issues involved in obtaining informed consent for medical research from mechanically ventilated, critically ill patients, in addition to the concerns that may arise when a legally authorized representative is asked to provide informed consent on behalf of these patients.

Identifiers

PMID30127668
PMCPMC6097714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.