Evidence map›Paper›PMID 30127604›Full record

ArticleInternational journal of nanomedicine2018

Comparative functional dynamics studies on the enzyme nano-bio interface.

Spencer E Thomas, Jeffrey Comer, Min Jung Kim, Shanna Marroquin, Vaibhav Murthy, Meghana Ramani, Tabetha Gaile Hopke, Jayden McCall, Seong-O Choi, Robert K DeLong

Open access · goldAbstract readComparative Study
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Spencer E ThomasNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Jeffrey ComerNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Min Jung KimNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Shanna MarroquinNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Vaibhav MurthyNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Meghana RamaniNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Tabetha Gaile HopkeDepartment of Biomedical Science, Missouri State University, Springfield, MO, USA.
Jayden McCallNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Seong-O ChoiNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Robert K DeLongNanotechnology Innovation Center of Kansas State, Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA, robertdelong@vet.k-state.edu.
Kansas State University · USMissouri State University · US

Funding

Anti-Cancer RNA NanoconjugatesR15CA139390 · NCI · MISSOURI STATE UNIVERSITY · PI DELONG, ROBERT K., GARRAD, RICHARD C · 2009 to 2013
$640k
NCI NIH HHS R15 CA139390
6 · The paper itself

Abstract

introductionBiomedical applications of nanoparticles (NPs) as enzyme inhibitors have recently come to light. Oxides of metals native to the physiological environment (eg, Fe, Zn, Mg, etc.) are of particular interest-especially the functional consequences of their enzyme interaction. MATERIALS AND

methodsHere, Fe

resultsAnalysis of possible trypsin cleavage sites suggest that cleavage mostly occurs in the range of residues 112-155 and 372-439, giving a major 45 kDa band. By 2-D PLDS, it is found that B

conclusionOverall the results suggest that B

Indexed as

3T3 CellsAnimalsArea Under CurveBoron CompoundsCircular DichroismCopperFirefly LuciferinKineticsLuciferasesMetal NanoparticlesMiceModels, MolecularOxidesSpectrometry, FluorescenceBoron CompoundsCopperFirefly LuciferinLuciferasesOxides2-D FDS2-dimensional fluorescence differenceAUCcorrected light intensity emittedemission wavelengthexcitation wavelengthRLUwavelength of max intensity

Identifiers

PMID30127604
PMCPMC6092129
OpenAlexW2887694515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.