Evidence map›Paper›PMID 30127594›Full record

ArticleDrug design, development and therapy2018

Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches.

Muhammad Tahir Aqeel, Nisar Ur-Rahman, Arif-Ullah Khan, Zaman Ashraf, Muhammad Latif, Hummera Rafique, Usman Rasheed

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Avicenna journal of phytomedicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Muhammad Tahir AqeelDepartment of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Pakistan.
Nisar Ur-RahmanDepartment of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Pakistan.
Arif-Ullah KhanRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Zaman AshrafDepartment of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan, mzchem@yahoo.com.
Muhammad LatifCollege of Medicine, Centre for Genetics and Inherited Diseases (CGID), Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
Hummera RafiqueDepartment of Chemistry, University of Gujrat, Gujrat, Pakistan.
Usman RasheedDepartment of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Pakistan.
COMSATS University Islamabad · PKAllama Iqbal Open University · PKRiphah International University · PKTaibah University · SAUniversity of Gujrat · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperlipidemia is a worth-mentioning risk factor in quickly expanding cardiovascular diseases, including myocardial infarction and, furthermore, in stroke.

methodsThe present work describes the synthesis of phenolic derivatives

resultsCompound

conclusionBased on our pharmacological evaluation, we may propose that compound

Indexed as

Computer-Aided DesignDrug DesignMolecular Docking SimulationAnimalsBinding SitesBiomarkersDisease Models, AnimalDown-RegulationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesHyperlipidemiasLipidsMaleMice, Inbred BALB CPhenolsBiomarkersHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesLipidsPhenolsantihyperlipidemicatorvastatinHMG CoA reductasein silico dockingphenolic derivativessynthesis

Identifiers

PMID30127594
PMCPMC6089105
OpenAlexW2886084256

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.