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ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2018

Invasive Fungal Infections in Acute Promyelocytic Leukemia on Dual Differentiating Agents: Real World Data.

Uday Yanamandra, Parathan Karunakaran, Alka Khadwal, Gaurav Prakash, Deepesh Lad, Shano Naseem, Neelam Varma, Arunaloke Chakrabarti, Subhash Varma, Pankaj Malhotra

Open access · bronzeAbstract read
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Disseminated Aspergillus Flavus Infection in High-Risk Acute Promyelocytic Leukemia: A Case for Early Recognition and Pharmacokinetic Guided Treatment Approach.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  3. High Risk Acute Promyelocytic Leukemia - An Enigma for Hematologists: Optimizing Treatment with APML-4 Protocol.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2022
    Article
  4. Stem Cell Transplantation in Multiple Myeloma: Very Much Alive and Kicking.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Uday Yanamandra1Department of Haematology and Stem Cell Transplant, Army Hospital (Research and Referral), Delhi, 110010 India.
Parathan Karunakaran2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Alka Khadwal2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Gaurav Prakash2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Deepesh Lad2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Shano Naseem3Department of Hematopathology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Neelam Varma3Department of Hematopathology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Arunaloke Chakrabarti4Department of Medical Microbiology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Subhash Varma2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Pankaj Malhotra2Department of Internal Medicine and Clinical Hematology, P.G.I.M.E.R, Chandigarh, U.T 160012 India.
Post Graduate Institute of Medical Education and Research · INArmy Hospital Research and Referral · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive fungal infection (IFI) in patients with acute promyelocytic leukemia (APL) is a common phenomenon in developing countries. In a systematic study (Dual Inducing Differentiating agents-Indian Trial: DID-IT) using dual differentiating agents (ATO and ATRA) in 98 APL patients at our center we report 18.3% incidence of IFI (n-18). Among all cases of IFI three were definitive, 14 were probable and one was possible IFI. We conclude that incidence of IFI in APL is affected by environmental and therapy related factors and mere usage of dual differentiating agents need not necessarily decrease the incidence of fungal infections.

Indexed as

APLATOATRAFungal infection

Identifiers

PMID30127554
PMCPMC6081339
OpenAlexW2766070857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.