ArticleScientific reports2018
Inertial-Based Filtration Method for Removal of Microcarriers from Mesenchymal Stem Cell Suspensions.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Opening New Horizons: Advanced Hematopoietic Stem Cell Expansion Strategies Bridging Cord Blood Therapy from Bench To Bedside.Stem cell reviews and reports · 2026Review
- Comparative antioxidant activity of four Omani medicinal plants:Open veterinary journal · 2025Article
- A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section.Sensors (Basel, Switzerland) · 2024Article
- Article
- High-throughput isolation of cancer cells in spiral microchannel by changing the direction, magnitude and location of the maximum velocity.Scientific reports · 2023Article
- Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer.Micromachines · 2022Article
- A modular 3D printed microfluidic system: a potential solution for continuous cell harvesting in large-scale bioprocessing.Bioresources and bioprocessing · 2022Article
- Engineered cell-laden thermosensitive poly(N-isopropylacrylamide)-immobilized gelatin microspheres as 3D cell carriers for regenerative medicine.Materials today. Bio · 2022Article
- A scalable system for generation of mesenchymal stem cells derived from induced pluripotent cells employing bioreactors and degradable microcarriers.Stem cells translational medicine · 2021Article
- Article
- Reengineering Bone-Implant Interfaces for Improved Mechanotransduction and Clinical Outcomes.Stem cell reviews and reports · 2020Review
- Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration.Biotechnology and bioengineering · 2020Article
- Mussel inspired ZIF8 microcarriers: a new approach for large-scale production of stem cells.RSC advances · 2020Article
- 3D Printing of Inertial Microfluidic Devices.Scientific reports · 2020Article
- Microcarriers for Upscaling Cultured Meat Production.Frontiers in nutrition · 2020Review
- Spiral microfluidic devices for cell separation and sorting in bioprocesses.Biomicrofluidics · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapidly evolving cell-based therapies towards clinical trials demand alternative approaches for efficient expansion of adherent cell types such as human mesenchymal stem cells (hMSCs). Using microcarriers (100-300 µm) in a stirred tank bioreactor offers considerably enhanced surface to volume ratio of culture environment. However, downstream purification of the harvested cell product needs to be addressed carefully due to distinctive features and fragility of these cell products. This work demonstrates a novel alternative approach which utilizes inertial focusing to separate microcarriers (MCs) from the final cell suspension. First, we systematically investigated MC focusing dynamics inside scaled-up curved channels with trapezoidal and rectangular cross-sections. A trapezoidal spiral channel with ultra-low-slope (Tan(α) = 0.0375) was found to contribute to strong MC focusing (~300 < Re < ~400) while managing high MC volume fractions up to ~1.68%. Accordingly, the high-throughput trapezoidal spiral channel successfully separated MCs from hMSC suspension with total cell yield~94% (after two passes) at a high volumetric flow rate of ~30 mL/min (Re~326.5).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.