Evidence map›Paper›PMID 30127525›Full record

ArticleScientific reports2018

Iridium-based probe for luminescent nitric oxide monitoring in live cells.

Chun Wu, Ke-Jia Wu, Tian-Shu Kang, Hui-Min David Wang, Chung-Hang Leung, Jin-Biao Liu, Dik-Lung Ma

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Chun WuDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
Ke-Jia WuState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Tian-Shu KangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Hui-Min David WangGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, China.
Chung-Hang LeungState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.ORCID 0000-0003-2988-3786
Jin-Biao LiuDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. liujbgood@hotmail.com.ORCID 0000-0002-5038-6541
Dik-Lung MaDepartment of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. edmondma@hkbu.edu.hk.
Hong Kong Baptist University · HKUniversity of Macau · MONational Chung Hsing University · TW

Funding

Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF) HMRF/14150561Hong Kong Baptist University (HKBU) FRG2/16-17/007, FRG2/17-18/003Innovation and Technology Commission (Innovation and Technology Commission of Hong Kong Special Administrative Government) ITS/260/16FXNational Natural Science Foundation of China (National Science Foundation of China) 21575121, 21775131, 21628502Research Grants Council, University Grants Committee (RGC, UGC) HKBU/12301115Universidade de Macau (University of Macau) MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS
6 · The paper itself

Abstract

Nitric oxide (NO) is an intra- and extracellular messenger with important functions during human physiology process. A long-lived luminescent iridium(III) complex probe 1 has been designed and synthesized for the monitoring of NO controllably released from sodium nitroprusside (SNP). Probe 1 displayed a 15-fold switch-on luminescence in the presence of SNP at 580 nm. The probe exhibited a linear response towards SNP between 5 to 25 μM with detection limit at 0.18 μM. Importantly, the luminescent switch-on detection of NO in HeLa cells was demonstrated. Overall, complex 1 has the potential to be applied for NO tracing in complicated cellular environment.

Indexed as

Cell Line, TumorHeLa CellsHumansIndicators and ReagentsIridiumLimit of DetectionLuminescenceLuminescent AgentsLuminescent MeasurementsNitric OxideNitroprussideOrganometallic CompoundsIndicators and ReagentsIridiumLuminescent AgentsNitric OxideNitroprussideOrganometallic Compounds

Identifiers

PMID30127525
PMCPMC6102254
OpenAlexW2887395237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.