ArticleNature communications2018
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
111 citing papers in PubMed, 166 citations in OpenAlex.
- Temporal Dynamics of Dorsal-Striatal Protein Networks During Radial-Arm Maze Training.Neuroinformatics · 2026Article
- Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role forbioRxiv : the preprint server for biology · 2026Article
- Circadian rhythm disruption alters rhythmic properties of clock and memory gene expression in the hippocampi of rats.bioRxiv : the preprint server for biology · 2026Article
- Advances and clinical potential of epigenome editing.Cellular and molecular life sciences : CMLS · 2026Review
- Old mice fail to integrate a memory update into an existing hippocampal engram.bioRxiv : the preprint server for biology · 2026Article
- COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age.Research square · 2026Article
- Single-cell resolution spatial transcriptomic signature of the retrosplenial cortex during memory consolidation.Molecular psychiatry · 2026Article
- The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP.Cell reports · 2026Article
- Cry2 deficiency leads to cognitive impairment through the microbiota-gut-brain axis mediated S1P/NLRP3/IL-1β pathway in mice.Journal of neuroinflammation · 2026Article
- Epigenome editing based treatment: Progresses and challenges.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- Inhibition of histone lysine demethylase restores learning and memory in aged mice.bioRxiv : the preprint server for biology · 2025Article
- Intersection of transient cell states with stable cell types in hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression.Biology of sex differences · 2025Article
- Increased DNA methylation of Igf2 in the male hippocampus regulates age-related deficits in synaptic plasticity and memory.Brain research bulletin · 2025Article
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- HDAC3 as an Emerging Therapeutic Target for Alzheimer's Disease and other Neurological Disorders.Molecular neurobiology · 2025Review
- Chronic circadian disruption in adolescent mice impairs hippocampal memory disrupting gene expression oscillations.Scientific reports · 2025Article
- HDAC3 Serine 424 Phospho-mimic and Phospho-null Mutants Bidirectionally Modulate Long-Term Memory Formation and Synaptic Plasticity in the Adult and Aging Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- A Pocket Guide for the Experimenter Studying Daily Rhythms in Memory-Related Behavior.Current protocols · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired hippocampal memory. Here, we show that the repressive histone deacetylase HDAC3 restricts long-term memory, synaptic plasticity, and experience-induced expression of the circadian gene Per1 in the aging hippocampus without affecting rhythmic circadian activity patterns. We also demonstrate that hippocampal Per1 is critical for long-term memory formation. Together, our data challenge the traditional idea that alterations in the core circadian clock drive circadian-related changes in memory formation and instead argue for a more autonomous role for circadian clock gene function in hippocampal cells to gate the likelihood of long-term memory formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.