ArticleScientific reports2018
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023Pooled it
- Regulatory T cells in axial spondyloarthritis.Communications biology · 2026Review
- Transition From Juvenile Dermatomyositis to Spondyloarthritis: A Novel Overlapping Inflammatory Phenotype.ACR open rheumatology · 2026Article
- Impact of ERAP1 downregulation on the pathogenesis of DSS-induced colitis and therapeutic response to sulfasalazine.Frontiers in immunology · 2025Article
- A Multitrait Analysis of Genome-Wide Association Study Reveals the Shared Genetic Architecture Between Inflammatory Bowel Disease and Ankylosing Spondylitis.Mediators of inflammation · 2025Article
- Decoding the inflammatory-osteogenic axis in ankylosing spondylitis: mechanisms, dysregulation, and emerging therapeutic interventions.Frontiers in immunology · 2025Review
- Characterisation of gut microbiota composition in patients with axial spondyloarthritis and its modulation by TNF inhibitor treatment.RMD open · 2023Article
- Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants.BMC gastroenterology · 2022Article
- ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses.BMC immunology · 2022Article
- A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys.Arthritis research & therapy · 2022Article
- Vesicular traffic-mediated cell-to-cell signaling at the immune synapse in Ankylosing Spondylitis.Frontiers in immunology · 2022Review
- Lessons on SpA pathogenesis from animal models.Seminars in immunopathology · 2021Review
- The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis.Frontiers in cell and developmental biology · 2021Review
- Review
- Loss and gain of bone in spondyloarthritis: what drives these opposing clinical features?Therapeutic advances in musculoskeletal disease · 2020Review
- Looking Beyond Th17 Cells: A Role for Tr1 Cells in Ankylosing Spondylitis?Frontiers in immunology · 2020Review
- Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NADFrontiers in immunology · 2020Article
- Dendritic cells in the pathogenesis of ankylosing spondylitis and axial spondyloarthritis.Clinical rheumatology · 2019Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Ankylosing spondylitis (AS) is a prototypical sero-negative autoimmune disease that affects millions worldwide. Single nucleotide polymorphisms in the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene have been linked to AS via GWAS studies, however, the exact mechanism as to how ERAP1 contributes to pathogenesis of AS is not understood. We undertook µCT imaging and histologic analysis to evaluate bone morphology of the axial skeletons of ERAP1
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