ArticleScientific reports2018
JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pharmacological inhibition of the Janus Kinases enhances ASCL1 protein stability and transcriptional activity.Molecular biology reports · 2025Article
- Neuroinflammation is responsible for pain in endometriosis - targeting the JAK-STAT pathway and mast cell activation.Frontiers in immunology · 2025Review
- Review
- Molecular Dynamics of Cytokine Interactions and Signalling of Mesenchymal Stem Cells Undergoing Directed Neural-like Differentiation.Life (Basel, Switzerland) · 2022Article
- Review
- Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain.Nature communications · 2021Article
- Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem/Progenitor Cells.Frontiers in cell and developmental biology · 2021Article
- A continuation method for spatially discretized models with nonlocal interactions conserving size and shape of cells and lattices.Journal of mathematical biology · 2020Article
- Article
- Article
- The proneural wave in theeLife · 2019Article
- Novel Strategies for the Generation of Neuronal Diversity: Lessons From the Fly Visual System.Frontiers in molecular neuroscience · 2019Review
- Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe.Neural development · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.
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