Evidence map›Paper›PMID 30127396›Full record

ArticleInternational journal of impotence research2019

S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.

Parviz K Kavoussi, Ryan P Smith, Janine L Oliver, Raymond A Costabile, William D Steers, Katie Brown-Steinke, Kimberly de Ronde, Jeffrey J Lysiak, Lisa A Palmer

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of impotence research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Review
  4. eNOS S-nitrosylation in erectile function.International journal of impotence research · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Parviz K KavoussiDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Ryan P SmithDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. rps2k@virginia.edu.
Janine L OliverDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Raymond A CostabileDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
William D SteersDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Katie Brown-SteinkeDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Kimberly de RondeDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Jeffrey J LysiakDepartment of Urology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Lisa A PalmerDepartment of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
University of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal and endothelial nitric oxide synthases (nNOS and eNOS respectively) play major roles in generating the nitric oxide bioactivity necessary for erectile function. S-nitrosylation has been shown to regulate NOS activity. The presence of S-nitrosylated NOS in the penis and the impact of NOS S-nitrosylation/denitrosylation on erectile function were examined. S-nitrosylated forms of NOS were identified by biotin-switch assay followed by western blot analysis. Erectile function in S-nitrosoglutathione reductase deficient (GSNO

Indexed as

Aldehyde OxidoreductasesAnimalsEndothelium, VascularErectile DysfunctionMaleMiceMice, KnockoutNitric Oxide Synthase Type IIIPenile ErectionPenisAldehyde Oxidoreductasesformaldehyde dehydrogenase, glutathione-independentNitric Oxide Synthase Type III

Identifiers

PMID30127396
OpenAlexW2886258715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.