Evidence map›Paper›PMID 30127380›Full record

ArticleCellular & molecular immunology2019

Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis.

Wen-Yu Chen, Sheng-Yang Wu, Ta-Chun Lin, Shuei-Liong Lin, Betty A Wu-Hsieh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RIPK3: A New Player in Renal Fibrosis.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wen-Yu ChenGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, China.
Sheng-Yang WuGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, China.
Ta-Chun LinGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, China.
Shuei-Liong LinGraduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan, China.
Betty A Wu-HsiehGraduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, China. bwh@ntu.edu.tw.
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We discovered that, while C. albicans infection induced renal fibrosis in both transgenic and littermate control mice, the transgenic mice had significantly lower levels of Acta2, Col1a2, Col3a1, and Col4a1 mRNA transcripts compared to the controls. KIM-1, an emerging biomarker for kidney injury, along with Tnf, Il6, and Tgfb1 transcripts, were lower in infected transgenic mice, and yet, the levels of Il10 remained comparable to the controls. While renal CD45

Indexed as

AnimalsCandida albicansCandidiasisCell Adhesion MoleculesCells, CulturedDC-Specific ICAM-3 Grabbing NonintegrinDendritic CellsDisease Models, AnimalEpithelial CellsFibrosisHumansKidneyLectins, C-TypeMiceMice, Transgenicp38 Mitogen-Activated Protein KinasesCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinLectins, C-Typep38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-rafReceptors, Cell SurfaceTransforming Growth Factor beta1Candida albicansDC-SIGNRaf-1Renal fibrosisTGF-β1

Identifiers

PMID30127380
PMCPMC6460490
OpenAlexW2888116829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.