Evidence map›Paper›PMID 30127374›Full record

Trial reportEuropean journal of clinical nutrition2019

Effect of flaxseed consumption on flow-mediated dilation and inflammatory biomarkers in patients with coronary artery disease: a randomized controlled trial.

Nafiseh Khandouzi, Ali Zahedmehr, Ali Mohammadzadeh, Hamid Reza Sanati, Javad Nasrollahzadeh

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04767230 (The Effect of a Healthy Diet Containing Flaxseed and Olive Oil Compared With Healthy Dietary Advice on Cardiovascular Disease Risk Markers in Patients With Coronary Artery Disease), which is not on this map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04767230 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of a Healthy Diet Containing Flaxseed and Olive Oil Compared With Healthy Dietary Advice on Cardiovascular Disease Risk Markers in Patients With Coronary Artery Disease

TypeinterventionalSponsorShahid Beheshti University of Medical SciencesRan2021 to 2022Enrolled50ConditionsCoronary Artery DiseaseArmsDietary Intervention
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Inflammation as a mediator of arterial ageing.Experimental physiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nafiseh KhandouziDepartment of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali ZahedmehrCardiovascular Intervention Research Center, Shahid Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
Ali MohammadzadehShadid Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
Hamid Reza SanatiCardiovascular Intervention Research Center, Shahid Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
Javad NasrollahzadehDepartment of Clinical Nutrition & Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. jnasrollahzadeh@gmail.com.
Shaheed Rajaei Cardiovascular Medical and Research Center · IRIran University of Medical Sciences · IRNational Nutrition and Food Technology Research Institute · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveAvailable data indicate a possible beneficial effect of flaxseed on cardiovascular disease, but limited studies have evaluated the effects of flaxseed on endothelial dysfunction and biomarkers of inflammation in patients with coronary artery disease (CAD). The purpose of the present study was to examine the effect of flaxseed consumption on flow-mediated dilation (FMD) and inflammatory markers in CAD patients. SUBJECTS/

methodIn this randomized controlled parallel trial, 50 patients with CAD of both genders were randomly allocated to 12 weeks consumption of flaxseed (30 g/day) or usual care control. Before and after the intervention, changes in brachial FMD and plasma high-sensitivity C-reactive protein (hs-CRP), interleukine-6 (IL-6), and tumor necrosis factor-α (TNF-α) were measured.

resultsForty-four participants (aged 56.43 ± 8.21 years; BMI 26.65 ± 2.44 kg/m

conclusionsThe results of this study indicate that by adding flaxseed to diet of CAD patients, it is possible to improve FMD and plasma levels of inflammatory markers.

Indexed as

FlaxSeedsAdultAgedBiomarkersBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinFemaleHumansInflammationInterleukin-6MaleMiddle AgedPulsatile FlowTreatment OutcomeBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID30127374
OpenAlexW2886570690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.