ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Article
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Multisystemic Consequences of Brain-Derived Neurotrophic Factor (BDNF) Haploinsufficiency in the SD-BDNFtm1sage Rat Model.International journal of molecular sciences · 2026Review
- Chemoarchitectural studies of the rat hypothalamus and zona incerta.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal correlates of fear generalization during endocannabinoid depletion.The Journal of clinical investigation · 2025Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus.Behavioural brain research · 2025Article
- A history of avoidance does not impact extinction learning in male rats.NPJ science of learning · 2024Article
- PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION.bioRxiv : the preprint server for biology · 2024Article
- Ventral Hippocampal Input to Infralimbic Cortex Is Necessary for the Therapeutic-Like Effects of Extinction in Stressed Rats.The international journal of neuropsychopharmacology · 2023Article
- Intra-mPFC injection of sodium butyrate promotes BDNF expression and ameliorates extinction recall impairment in an experimental paradigm of post-traumatic stress disorder.Iranian journal of basic medical sciences · 2022Article
- Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?Neuroscience and biobehavioral reviews · 2021Review
- Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- BEHAVIORAL AND NEUROBIOLOGICAL MECHANISMS OF PAVLOVIAN AND INSTRUMENTAL EXTINCTION LEARNING.Physiological reviews · 2021Review
- Multimodal examination of emotion processing systems associated with negative affectivity across early childhood.Developmental cognitive neuroscience · 2021Article
- Genetic Depletion of BDNF Impairs Extinction Learning of a Spatial Appetitive Task in the Presence or Absence of the Acquisition Context.Frontiers in behavioral neuroscience · 2021Article
- Melamine disrupts spatial reversal learning and learning strategy via inhibiting hippocampal BDNF-mediated neural activity.PloS one · 2021Article
- Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis.Translational psychiatry · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) is critical for establishing activity-related neural plasticity. There is increasing interest in the mechanisms of active avoidance and its extinction, but little is known about the role of BDNF in these processes. Using the platform-mediated avoidance task combined with local infusions of an antibody against BDNF, we show that blocking BDNF in either prelimbic (PL) or infralimbic (IL) medial prefrontal cortex during extinction training impairs subsequent recall of extinction of avoidance, differing from extinction of conditioned freezing. By combining retrograde tracers with BDNF immunohistochemistry, we show that extinction of avoidance increases BDNF expression in ventral hippocampal (vHPC) neurons, but not amygdala neurons, projecting to PL and IL. Using the CRISPR/Cas9 system, we further show that reducing BDNF production in vHPC neurons impairs recall of avoidance extinction. Thus, the vHPC may mediate behavioral flexibility in avoidance by driving extinction-related plasticity via BDNFergic projections to both PL and IL. These findings add to the growing body of knowledge implicating the hippocampal-prefrontal pathway in anxiety-related disorders and extinction-based therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.