ArticleScientific reports2018
Hydrodynamic trapping measures the interaction between membrane-associated molecules.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Correlation of G protein-coupled receptor and tumor microenvironment with gastric cancer outcomes and therapies.Chinese medical journal · 2026Article
- Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enforced Dimerization of CD45 by the Adenovirus E3/49K Protein Inhibits T Cell Receptor Signaling.Journal of virology · 2023Article
- Single-cell measurements of two-dimensional binding affinity across cell contacts.Biophysical journal · 2021Article
- Cooperativity of α-Synuclein Binding to Lipid Membranes.ACS chemical neuroscience · 2021Article
- Molecular height measurement by cell surface optical profilometry (CSOP).Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Calcium Signaling in T Cells Is Induced by Binding to Nickel-Chelating Lipids in Supported Lipid Bilayers.Frontiers in physiology · 2020Article
- Physical Constraints and Forces Involved in Phagocytosis.Frontiers in immunology · 2020Review
- Dimensions and Interactions of Large T-Cell Surface Proteins.Frontiers in immunology · 2018Review
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Authors and funding
6 authors.
Funding
Abstract
How membrane proteins distribute and behave on the surface of cells depends on the molecules' chemical potential. However, measuring this potential, and how it varies with protein-to-protein distance, has been challenging. Here, we present a method we call hydrodynamic trapping that can achieve this. Our method uses the focused liquid flow from a micropipette to locally accumulate molecules protruding above a lipid membrane. The chemical potential, as well as information about the dimensions of the studied molecule, are obtained by relating the degree of accumulation to the strength of the trap. We have used this method to study four representative proteins, with different height-to-width ratios and molecular properties; from globular streptavidin, to the rod-like immune cell proteins CD2, CD4 and CD45. The data we obtain illustrates how protein shape, glycosylation and flexibility influence the behaviour of membrane proteins, as well as underlining the general applicability of the method.
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