ReviewBrain sciences2018
The Current State of Deep Brain Stimulation for Chronic Pain and Its Context in Other Forms of Neuromodulation.
Review in Brain sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Deep brain stimulation and motor cortex stimulation for central post-stroke pain: a systematic review and meta-analysis.Pain medicine (Malden, Mass.) · 2025Pooled it
- A systematic review of deep brain stimulation for substance use disorders.Translational psychiatry · 2024Pooled it
- Deep brain stimulation of the brainstem.Brain : a journal of neurology · 2021Pooled it
- Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.Journal of neural engineering · 2026Trial
- Transcutaneous Auricular Neurostimulation Modulates Pain Perception in Survivors of Stroke With Chronic Upper-Extremity Pain: A Randomized, Sham-Controlled Pilot Study.Neuromodulation : journal of the International Neuromodulation Society · 2026Trial
- Toward Individualized Deep Brain Stimulation: A Stereoelectroencephalography-Based Workflow for Neurostimulation Target Identification.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Electromagnetic neuromodulation for chronic pain: historical context, contemporary modalities, and evidence gaps.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification.bioRxiv : the preprint server for biology · 2025Article
- Article
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- Transforming Chronic Pain Management: Integrating Neuromodulation with Advanced Technologies to Tackle Cognitive Dysfunction - A Narrative Review.Journal of pain research · 2025Review
- Deep brain stimulation for chronic pain: mechanisms, clinical applications, limitations, and future directions.Frontiers in medicine · 2025Review
- A Synchronous iEEG Data Acquisition Framework for Dual Brain Interchange Systems.The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems · 2024Article
- Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024Review
- Benchmarking signal quality and spatiotemporal distribution of interictal spikes in prolonged human iEEG recordings using CorTec wireless brain interchange.Scientific reports · 2024Article
- Predictive modeling of sensory responses in deep brain stimulation.Frontiers in neurology · 2024Article
- Deciphering Authentic Nociceptive Thalamic Responses in Rats.Research (Washington, D.C.) · 2024Article
- The cingulum: a central hotspot for the battle against chronic intractable pain?Brain communications · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic intractable pain is debilitating for those touched, affecting 5% of the population. Deep brain stimulation (DBS) has fallen out of favour as the centrally implantable neurostimulation of choice for chronic pain since the 1970⁻1980s, with some neurosurgeons favouring motor cortex stimulation as the 'last chance saloon'. This article reviews the available data and professional opinion of the current state of DBS as a treatment for chronic pain, placing it in the context of other neuromodulation therapies. We suggest DBS, with its newer target, namely anterior cingulate cortex (ACC), should not be blacklisted on the basis of a lack of good quality study data, which often fails to capture the merits of the treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.