Evidence map›Paper›PMID 30127285›Full record

ArticleMolecules (Basel, Switzerland)2018

Suppression of Hepatitis C Virus Genome Replication and Particle Production by a Novel Diacylglycerol Acyltransferases Inhibitor.

Dahee Kim, Ja-Il Goo, Mi Il Kim, Sung-Jin Lee, Moonju Choi, Thoa Thi Than, Phuong Hong Nguyen, Marc P Windisch, Kyeong Lee, Yongseok Choi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Dahee KimCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. gkdlfnwhel@nate.com.
Ja-Il GooSchool of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea. lighthil@gmail.com.ORCID 0000-0002-6434-5636
Mi Il KimCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. aldlf998@dongguk.ac.kr.
Sung-Jin LeeCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. flatronsky@gmail.com.
Moonju ChoiCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. ryche99@naver.com.
Thoa Thi ThanHepatitis Research Laboratory, Department of Applied Molecular Virology, Institut Pasteur Korea, 696, Seongnam 13488, Korea. thoa.than@ip-korea.org.
Phuong Hong NguyenHepatitis Research Laboratory, Department of Applied Molecular Virology, Institut Pasteur Korea, 696, Seongnam 13488, Korea. phuong.nguyen@ip-korea.org.
Marc P WindischHepatitis Research Laboratory, Department of Applied Molecular Virology, Institut Pasteur Korea, 696, Seongnam 13488, Korea. marc.windisch@ip-korea.org.
Kyeong LeeCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. kaylee@dongguk.edu.
Yongseok ChoiSchool of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea. ychoi@korea.ac.kr.
Choongho LeeCollege of Pharmacy, Dongguk University, Goyang 10326, Korea. lkj640@gmail.com.
Dongguk University · KRInstitut Pasteur Korea · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diacylglycerol acyltransferases (DGATs) play a critical role in the biosynthesis of endogenous triglycerides (TGs) and formation of lipid droplets (LDs) in the liver. In particular, one member of DGATs, DGAT-1 was reported to be an essential host factor for the efficient production of hepatitis C virus (HCV) particles. By utilizing our previously characterized three different groups of twelve DGAT inhibitors, we found that one of the DGAT inhibitors, a 2-((4-adamantylphenoxy) methyl)-

Indexed as

Genome, ViralAdamantaneAntiviral AgentsCell LineCell SurvivalDiacylglycerol O-AcyltransferaseGene ExpressionHepacivirusHumansImidazolesRNASmall Molecule LibrariesVirionAdamantaneAntiviral AgentsDiacylglycerol O-AcyltransferaseImidazolesRNASmall Molecule LibrariesDGAT inhibitordiacylglycerol acyltransferase (DGAT)HCV genome replicationHCV particle productionhepatitis C virus (HCV)lipid droplet (LD)

Identifiers

PMID30127285
PMCPMC6222871
OpenAlexW2888161932

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.