ReviewNeural regeneration research2018
Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications.
Review in Neural regeneration research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Temporomandibular disorder in individuals with spinal cord injuries.The journal of spinal cord medicine · 2024Article
- Review
- Coding and long non-coding gene expression changes in the CNS traumatic injuries.Cellular and molecular life sciences : CMLS · 2022Review
- Ultrasound in Traumatic Spinal Cord Injury: A Wide-Open Field.Neurosurgery · 2021Article
- Prolonged Targeted Cardiovascular Epidural Stimulation Improves Immunological Molecular Profile: A Case Report in Chronic Severe Spinal Cord Injury.Frontiers in systems neuroscience · 2020Article
- Long non-coding RNAs in the spinal cord injury: Novel spotlight.Journal of cellular and molecular medicine · 2019Review
- Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury.Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardiovascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to improve immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genomics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.
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Registered trials
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