Evidence map›Paper›PMID 30127089›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

A Hypermorphic

Maximiliano Presa, Jeremy J Racine, Jennifer R Dwyer, Deanna J Lamont, Jeremy J Ratiu, Vishal Kumar Sarsani, Yi-Guang Chen, Aron Geurts, Ingo Schmitz, Timothy Stearns and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Regulation and Function of the Atypical IκBs-Bcl-3, IκBEuropean journal of immunology · 2025
    Review
  6. Review
  7. Review
  8. Applications of Genome-Editing Technologies for Type 1 Diabetes.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. CD11cFrontiers in immunology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Maximiliano PresaThe Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0002-0160-6528
Jeremy J RacineThe Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0001-5514-3074
Jennifer R DwyerThe Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0002-5893-6026
Deanna J LamontThe Jackson Laboratory, Bar Harbor, ME 04609.
Jeremy J RatiuThe Jackson Laboratory, Bar Harbor, ME 04609.
Vishal Kumar SarsaniThe Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0002-9272-3438
Yi-Guang ChenMedical College of Wisconsin, Milwaukee, WI 53226.
Aron GeurtsMedical College of Wisconsin, Milwaukee, WI 53226.
Ingo SchmitzSystems-Oriented Immunology and Inflammation Research Group, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany; and.ORCID 0000-0002-5360-0419
Timothy StearnsThe Jackson Laboratory, Bar Harbor, ME 04609.
Jennifer AlloccoThe Jackson Laboratory, Bar Harbor, ME 04609.
Harold D ChapmanThe Jackson Laboratory, Bar Harbor, ME 04609.
David V SerrezeThe Jackson Laboratory, Bar Harbor, ME 04609; dave.serreze@jax.org.ORCID 0000-0001-7614-5925
Jackson Laboratory · USMedical College of Wisconsin · USHelmholtz Centre for Infection Research · DE

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
The Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI LUTZ, CATHLEEN M · 2015 to 2019
$10.2M
Diabetogenic Role of MHC Class I Alleles in NOD MiceR01DK046266 · NIDDK · JACKSON LABORATORY · PI SERREZE, DAVID V · 2000 to 2018
$7.2M
B-lymphocyte Targeting Therapies for Autoimmune DiabetesR01DK095735 · NIDDK · JACKSON LABORATORY · PI SERREZE, DAVID V · 2013 to 2025
$6.2M
Mechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 DiabetesR01DK107541 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, RIDGWAY, WILLIAM M · 2016 to 2025
$5.6M
Discovery and Functional Studies of Genes for T1D GWAS Susceptibility LociDP3DK097605 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, GEURTS, ARON M · 2012 to 2012
$4.3M
Advancing HLA-"Humanized" Models for T1D Therapy DevelopmentF32DK111078 · NIDDK · JACKSON LABORATORY · PI RACINE, JEREMY J · 2016 to 2016
$58k
DIABETOGENIC ROLE OF H-2G7 CLASS I ALLELES IN NOD MICER29DK046266 · NIDDK · JACKSON LABORATORY · PI SERREZE, DAVID V. · 1993 to 1998
–
NCI NIH HHS P30 CA034196NIDDK NIH HHS DP3 DK097605NIDDK NIH HHS F32 DK111078NIDDK NIH HHS R01 DK046266NIDDK NIH HHS R01 DK095735NIDDK NIH HHS R01 DK107541NIDDK NIH HHS R29 DK046266NIH HHS U54 OD020351
6 · The paper itself

Abstract

In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8

Indexed as

AllelesAnimalsAutoantigensCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedChromosomes, Human, Pair 7Clonal DeletionDiabetes Mellitus, Type 1Disease Models, AnimalDisease SusceptibilityHumansI-kappa B ProteinsIntracellular Signaling Peptides and ProteinsMiceMice, Inbred NODAutoantigensI-kappa B ProteinsIntracellular Signaling Peptides and ProteinsNfkbid protein, mouse

Identifiers

PMID30127089
PMCPMC6143397
OpenAlexW2888730979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.