Evidence map›Paper›PMID 30127086›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Differential Influence on Regulatory B Cells by T

Sophina H Taitano, Luciën E P M van der Vlugt, Molly M Shea, Jennifer Yang, Nicholas W Lukacs, Steven K Lundy

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Mechanism(s) of prolonged attenuation of allergic responses after modulation of idiotypic regulatory network.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sophina H TaitanoDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0001-9453-4043
Luciën E P M van der VlugtDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.
Molly M SheaDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-3661-5966
Jennifer YangDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109.
Nicholas W LukacsGraduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI 48109; and.ORCID 0000-0003-2403-6481
Steven K LundyDivision of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109; sklundy@med.umich.edu.ORCID 0000-0002-3655-2216
University of Michigan · US

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
B Cell Exosome and Nanoparticle Treatment of Allergic AsthmaR21AI115117 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUNDY, STEVEN K. · 2015 to 2016
$426k
Enhancing Killer B Lymphocyte Function as a Treatment for Allergic AsthmaR03AI105029 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUNDY, STEVEN K. · 2013 to 2014
$156k
NIAID NIH HHS R03 AI105029NIAID NIH HHS R21 AI115117NIAID NIH HHS T32 AI007413
6 · The paper itself

Abstract

The role of regulatory B cells (Bregs) in modulating immune responses and maintaining tolerance are well established. However, how cytokines present during immune responses affect Breg growth and function are not as well defined. Previously, our laboratory reported IL-5- and mCD40L-expressing fibroblast (mCD40L-Fb) stimulation induced IL-10 production from murine B cells. The current study investigated the phenotype and functional relevance of IL-10- producing B cells from this culture. We found IL-5/mCD40L-Fb stimulation induced IL-10 production exclusively from CD5

Indexed as

AllergensAnimalsAsthmaB-Lymphocytes, RegulatoryCD40 LigandCells, CulturedCytokinesDisease Models, AnimalFemaleHumansImmune ToleranceImmunomodulationMiceMice, Inbred C57BLOvalbuminRespiratory HypersensitivityAllergensCD40 LigandCytokinesOvalbumin

Identifiers

PMID30127086
PMCPMC6143409
OpenAlexW2888221186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.