ArticleBMJ open2018
Gout and hearing impairment in the elderly: a retrospective cohort study using the US Medicare claims data.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Hyperuricemia beyond gout: an emerging risk factor for sensorineural hearing loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Metabolomic and Cellular Mechanisms of Drug-Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Risk of Sudden Sensorineural Hearing Loss in Patients with Gout: A Population-Level Study in a South Korean National Health Screening Cohort.Journal of clinical medicine · 2025Article
- Association between hearing loss and gout based on National Health and Nutrition Examination Survey and Mendelian randomization analysis.Scientific reports · 2024Article
- Case Report: A rare case of bilateral middle ear tophaceous gout.Frontiers in surgery · 2024Article
- Association between Hyperuricemia and Hearing Impairment: Results from the Korean National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2023Article
- Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss.Biomolecules · 2022Article
- Gout with Hearing Loss.Rheumatology and immunology research · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate whether gout is associated with a higher risk of hearing loss in older adults.
designRetrospective cohort study.
settingUSA.
participants5% random sample of US Medicare claims 2006-2012, representative of US adults aged 65 years or older. PRIMARY AND SECONDARY OUTCOMES: Incident (new) hearing loss identified by the presence of at least two claims at least 4 weeks apart with an International Classification of Diseases, Ninth Revision, 389.xx, with no respective claim in the baseline 1-year observation period.
resultsAmong the 1.71 million eligible people, 89 409 developed incident hearing impairment. The crude incidence rates of incident hearing impairment in people with versus without gout were 16.9 vs. 8.7 per 1000 person-years. Using Cox regression analyses adjusted for demographics, medical comorbidity and common cardiovascular and gout medications, we found that gout was associated with a significantly higher HR of incident hearing impairment, HR was 1.44 (95% CI 1.40 to 1.49, p<0.0001). Findings were confirmed in sensitivity analyses that substituted continuous Charlson-Romano Index with categorical variable or all comorbidities and additionally cardiovascular risk factors, with minimal attenuation of HR.
conclusionsGout is associated with a higher risk of development of hearing loss in older adults. Future studies need to assess the underlying mechanisms of this association.
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