Evidence map›Paper›PMID 30127001›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Two novel protein

Hideyuki Takeuchi, Michael Schneider, Daniel B Williamson, Atsuko Ito, Megumi Takeuchi, Penny A Handford, Robert S Haltiwanger

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments.Chembiochem : a European journal of chemical biology · 2026
    Article
  4. Article
  5. Glycan-related genes and genetic disorders.Journal of human genetics · 2026
    Review
  6. Sweet spots of O-glucosylation.Nature chemical biology · 2025
    Article
  7. Article
  8. Article
  9. DifferentialProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hideyuki TakeuchiComplex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602.
Michael SchneiderDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11795.
Daniel B WilliamsonComplex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602.
Atsuko ItoComplex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602.
Megumi TakeuchiComplex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602.
Penny A HandfordDepartment of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.
Robert S HaltiwangerComplex Carbohydrate Research Center, The University of Georgia, Athens, GA 30602; rhalti@uga.edu.
University of Georgia · USStony Brook University · USUniversity of Oxford · GB

Funding

O-Glycosylation of Epidermal Growth Factor-like MotifsR01GM061126 · NIGMS · UNIVERSITY OF GEORGIA · PI HALTIWANGER, ROBERT S. · 2001 to 2021
$9.1M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
NIGMS NIH HHS R01 GM061126NIGMS NIH HHS T32 GM107004
6 · The paper itself

Abstract

The Notch-signaling pathway is normally activated by Notch-ligand interactions. A recent structural analysis suggested that a novel

Indexed as

AnimalsGlucosyltransferasesGlycosylationHEK293 CellsHumansMiceNIH 3T3 CellsProtein TransportReceptor, Notch1Receptor, Notch2Receptor, Notch3Repetitive Sequences, Amino AcidSignal TransductionGlucosyltransferasesNOTCH1 protein, humanNOTCH2 protein, humanNOTCH3 protein, humanPOGLUT1 protein, humanReceptor, Notch1Receptor, Notch2Receptor, Notch3developmentglycosyltransferasesNotchO-glucosesignal transduction

Identifiers

PMID30127001
PMCPMC6130362
OpenAlexW2888275449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.