ArticleProceedings of the National Academy of Sciences of the United States of America2018
Nonuniformity in ligaments is a structural strategy for optimizing functionality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Giving It a Twist: One-Step Fabrication of Aligned Biomimetic Yarn Scaffolds via Rotational Melt Electrofibrillation.Advanced healthcare materials · 2026Article
- Preventive effect of probiotics on periodontal ligament in a rat model of anorexia nervosa.Scientific reports · 2025Article
- Periodontal ligament and alveolar bone remodeling during long orthodontic tooth movement analyzed by a novel user-independent 3D-methodology.Scientific reports · 2023Article
- A viscoelastic alginate-based hydrogel network coordinated with spermidine for periodontal ligament regeneration.Regenerative biomaterials · 2023Article
- Fluid flow shear stress and tissue remodeling-an orthodontic perspective: evidence synthesis and differential gene expression network analysis.Frontiers in bioengineering and biotechnology · 2023Article
- The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development.Journal of dental research · 2022Article
- Structural characteristics of periodontal ligaments in the pig model with experimental periodontitis.International journal of translational science · 2022Article
- Extracellular Matrix-Oriented Proteomic Analysis of Periodontal Ligament Under Mechanical Stress.Frontiers in physiology · 2022Article
- The effect of aging on the nanostructure of murine alveolar bone and dentin.Journal of bone and mineral metabolism · 2021Article
- Tooth attachment and pleurodont implantation in lizards: Histology, development, and evolution.Journal of anatomy · 2021Article
- Nonuniformity in Periodontal Ligament: Mechanics and Matrix Composition.Journal of dental research · 2021Article
- The Topographical Optimization of 3D Microgroove Pattern Intervals for Ligamentous Cell Orientations: In Vitro.International journal of molecular sciences · 2020Article
- In situ AFM-based nanoscale rheology reveals regional non-uniformity in viscoporoelastic mechanical behavior of the murine periodontal ligament.Journal of biomechanics · 2020Article
- Quantitative characterizations of the Sharpey's fibers of rat molars.Journal of periodontal research · 2020Article
- Three-dimensional ultrastructural and histomorphological analysis of the periodontal ligament with occlusal hypofunction via focused ion beam/scanning electron microscope tomography.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Ligaments serve as compliant connectors between hard tissues. In that role, they function under various load regimes and directions. The 3D structure of ligaments is considered to form as a uniform entity that changes due to function. The periodontal ligament (PDL) connects the tooth to the bone and sustains different types of loads in various directions. Using the PDL as a model, employing a fabricated motorized setup in a microCT, we demonstrate that the fibrous network structure within the PDL is not uniform, even before the tooth becomes functional. Utilizing morphological automated segmentation methods, directionality analysis, as well as second harmonic generation imaging, we find high correlation between blood vessel distribution and fiber density. We also show a structural feature in a form of a dense collar around the neck of the tooth as well as a preferred direction of the fibrous network. Finally, we show that the PDL develops as a nonuniform structure, with an architecture designed to sustain specific types of load in designated areas. Based on these findings, we propose that ligaments in general should be regarded as nonuniform entities, structured already at developmental stages for optimal functioning under variable load regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.