Evidence map›Paper›PMID 30126986›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Structural basis for antibiotic resistance mediated by the

Caillan Crowe-McAuliffe, Michael Graf, Paul Huter, Hiraku Takada, Maha Abdelshahid, Jiří Nováček, Victoriia Murina, Gemma C Atkinson, Vasili Hauryliuk, Daniel N Wilson

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 101 citations in OpenAlex.

  1. Translation factors that keep the ribosome Pro-active.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Ribosomal protection as a linezolid resistance mechanism inAntimicrobial agents and chemotherapy · 2026
    Article
  9. Article
  10. Ribosomal protection as a linezolid resistance mechanism inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Linezolid in the Focus of Antimicrobial Resistance ofInternational journal of molecular sciences · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Caillan Crowe-McAuliffeInstitute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Michael GrafInstitute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Paul HuterInstitute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Hiraku TakadaDepartment of Molecular Biology, Umeå University, 90187 Umeå, Sweden.
Maha AbdelshahidInstitute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany.
Jiří NováčekCentral European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
Victoriia MurinaDepartment of Molecular Biology, Umeå University, 90187 Umeå, Sweden.
Gemma C AtkinsonDepartment of Molecular Biology, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0002-4861-4584
Vasili HauryliukDepartment of Molecular Biology, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0003-2389-5057
Daniel N WilsonInstitute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany; daniel.wilson@chemie.uni-hamburg.de.ORCID 0000-0003-3816-3828
Universität Hamburg · DEUmeå University · SECentral European Institute of Technology · CZUniversity of Tartu · EE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many Gram-positive pathogenic bacteria employ ribosomal protection proteins (RPPs) to confer resistance to clinically important antibiotics. In

Indexed as

Drug Resistance, BacterialAllosteric RegulationAnti-Bacterial AgentsATP-Binding Cassette TransportersBacillus subtilisBacterial ProteinsRibosomesRNA, TransferAnti-Bacterial AgentsATP-Binding Cassette TransportersBacterial ProteinsRNA, TransferABC ATPaseantibiotic resistancecryo-EMribosomeVmlR

Identifiers

PMID30126986
PMCPMC6130385
OpenAlexW2888642995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.