Evidence map›Paper›PMID 30126979›Full record

ArticleBlood2018

Duodenal-type and nodal follicular lymphomas differ by their immune microenvironment rather than their mutation profiles.

Johannes C Hellmuth, Abner Louissaint, Monika Szczepanowski, Sarah Haebe, Alessandro Pastore, Stefan Alig, Annette M Staiger, Sylvia Hartmann, Robert Kridel, Matthew D Ducar and 10 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. A genetic profiling guideline to support diagnosis and clinical management of lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
  2. Trial
  3. Blood · 2018
    Trial
  4. Ocular adnexa follicular lymphoma: clinicopathological study of 23 patients.Virchows Archiv : an international journal of pathology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Genetic alterations in mature B- and T-cell lymphomas - a practical guide to WHO-HAEM5.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Follicular lymphoma and marginal zone lymphoma: how many diseases?Virchows Archiv : an international journal of pathology · 2023
    Review
  14. Article
  15. Duodenal Follicular Lymphoma: Track or Treat?Digestive diseases and sciences · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Follicular lymphoma: updates for pathologists.Journal of pathology and translational medicine · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 3 countries.

Johannes C HellmuthDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.ORCID 0000-0001-8409-3037
Abner LouissaintDepartment of Pathology, Massachusetts General Hospital, Boston, MA.
Monika SzczepanowskiDepartment of Pathology, Hematopathology Section and Lymph Node Registry, and.
Sarah HaebeDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Alessandro PastoreHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3621-4807
Stefan AligDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Annette M StaigerDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
Sylvia HartmannDr. Senckenberg Institute of Pathology, University Hospital of Frankfurt, Frankfurt am Main, Germany.
Robert KridelPrincess Margaret Cancer Centre, Toronto, ON, Canada.
Matthew D DucarCenter for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA.
Peter KochUniversity Hospital Muenster, Department of Medicine A, Muenster, Germany.
Martin DreylingDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Martin-Leo HansmannDr. Senckenberg Institute of Pathology, University Hospital of Frankfurt, Frankfurt am Main, Germany.
German OttDepartment of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
Andreas RosenwaldInstitute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany.
Randy D GascoyneCentre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada.
David M WeinstockDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and.ORCID 0000-0002-8724-3907
Wolfgang HiddemannDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Wolfram KlapperDepartment of Pathology, Hematopathology Section and Lymph Node Registry, and.
Oliver WeigertDepartment of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany.ORCID 0000-0002-0987-7373
Dana-Farber Cancer Institute · USGerman Cancer Research Center · DEGoethe University Frankfurt · DEMunich Leukemia Laboratory (Germany) · DERobert Bosch Hospital · DEBC Cancer Agency · CAChristian-Albrechts-Universität zu Kiel · DEComprehensive Cancer Center Mainfranken · DECornell University · USLudwig-Maximilians-Universität München · DEMassachusetts General Hospital · USMemorial Sloan Kettering Cancer Center · USPrincess Margaret Cancer Centre · CAUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duodenal-type follicular lymphoma (DTFL) is a rare and highly indolent follicular lymphoma (FL) variant. It is morphologically and immunophenotypically indistinguishable from typical FL, characterized by restricted involvement of intestinal mucosa, and lacks extraintestinal manifestations. The molecular determinants of this distinct clinical behavior are largely unknown. Thirty-eight diagnostic biopsies from patients with DTFL were evaluated. The 10-year overall survival rate was 100% in clinically evaluable patients (n = 19). We compared the targeted mutation profile of DTFL (n = 31), limited-stage typical FL (LSTFL; n = 17), and advanced-stage typical FL (ASTFL; n = 241). The mutation frequencies of recurrently mutated genes, including

Indexed as

MutationAdultAgedAged, 80 and overBiomarkers, TumorCytokinesDNA-Binding ProteinsDNA Mutational AnalysisDuodenal NeoplasmsExomeFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansInflammationLymphoma, FollicularBiomarkers, TumorCytokinesDNA-Binding ProteinsKMT2D protein, humanNeoplasm Proteins

Identifiers

PMID30126979
OpenAlexW2888444682

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.