ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Across Species "Natural Ablation" Reveals the Brainstem Source of a Noninvasive Biomarker of Binaural Hearing.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Assessing hearing and hearing loss in mice with open-source system and auditory brainstem response (OpenSABR).Journal of neurophysiology · 2026Article
- The effects of interaural time and level differences on the binaural interaction component of the auditory brainstem response in Cope's gray treefrogs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- A tale of two ears: development of binaural auditory processing in the big brown bat.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Persistent impairment of spatial hearing and neural binaural interaction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Differences in auditory brainstem responses between laboratory-reared and wild-caught prairie voles (Microtus ochrogaster).PloS one · 2026Article
- An open-source system for recording the auditory brainstem response (ABR) and an example application in mice with hearing loss.bioRxiv : the preprint server for biology · 2025Article
- Developmental auditory deprivation in one ear impairs brainstem binaural processing and reduces spatial hearing acuity.PLoS biology · 2025Article
- Auditory brainstem responses in two closely related Peromyscus species (Peromyscus leucopus and Peromyscus maniculatus).The Journal of the Acoustical Society of America · 2025Article
- Neural and behavioral binaural hearing impairment and its recovery following moderate noise exposure.Hearing research · 2025Article
- Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Demyelination and NaeNeuro · 2024Article
- Rate dependent neural responses of interaural-time-difference cues in fine-structure and envelope.PeerJ · 2024Article
- Hearing ability of prairie voles (Microtus ochrogaster).The Journal of the Acoustical Society of America · 2024Article
- Bilateral and symmetric glycinergic and glutamatergic projections from the LSO to the IC in the CBA/CaH mouse.Frontiers in neural circuits · 2024Article
- Interaural frequency mismatch jointly modulates neural brainstem binaural interaction and behavioral interaural time difference sensitivity in humans.Hearing research · 2023Article
- The continued importance of comparative auditory research to modern scientific discovery.Hearing research · 2023Review
- Sensitivity to interaural level and time differences in individuals with autism spectrum disorder.Scientific reports · 2022Article
- Auditory brainstem development of naked mole-rats (Proceedings. Biological sciences · 2022Article
- Aging alters across-hemisphere cortical dynamics during binaural temporal processing.Frontiers in neuroscience · 2022Article
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Abstract
The binaural interaction component (BIC) of the auditory brainstem response is a noninvasive electroencephalographic signature of neural processing of binaural sounds. Despite its potential as a clinical biomarker, the neural structures and mechanism that generate the BIC are not known. We explore here the hypothesis that the BIC emerges from excitatory-inhibitory interactions in auditory brainstem neurons. We measured the BIC in response to click stimuli while varying interaural time differences (ITDs) in subjects of either sex from five animal species. Species had head sizes spanning a 3.5-fold range and correspondingly large variations in the sizes of the auditory brainstem nuclei known to process binaural sounds [the medial superior olive (MSO) and the lateral superior olive (LSO)]. The BIC was reliably elicited in all species, including those that have small or inexistent MSOs. In addition, the range of ITDs where BIC was elicited was independent of animal species, suggesting that the BIC is not a reflection of the processing of ITDs per se. Finally, we provide a model of the amplitude and latency of the BIC peak, which is based on excitatory-inhibitory synaptic interactions, without assuming any specific arrangement of delay lines. Our results show that the BIC is preserved across species ranging from mice to humans. We argue that this is the result of generic excitatory-inhibitory synaptic interactions at the level of the LSO, and thus best seen as reflecting the integration of binaural inputs as opposed to their spatial properties.
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