ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
A Neuronal Ensemble in the Rostral Agranular Insula Tracks Cocaine-Induced Devaluation of Natural Reward and Predicts Cocaine Seeking.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Distinct ensembles in the prelimbic cortex track different measures of motivation for cocaine and water reinforcers.bioRxiv : the preprint server for biology · 2026Article
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Sex differences in oscillatory signaling dynamics in the prelimbic cortex and nucleus accumbens core during negative affect.Behavioural brain research · 2025Article
- Distinct populations suppress or escalate intake of cocaine paired with aversive quinine.Drug and alcohol dependence · 2024Article
- RECORD, a high-throughput, customizable system that unveils behavioral strategies leveraged by rodents during foraging-like decision-making.Communications biology · 2024Article
- Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets.Addiction neuroscience · 2024Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Prelimbic Cortex Activity during a Distress Tolerance Task Predicts Cocaine-Seeking Behavior in Male, But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Transforming experiences: Neurobiology of memory updating/editing.Frontiers in systems neuroscience · 2023Review
- GABAFrontiers in psychiatry · 2022Review
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Circuit selectivity in drug versus natural reward seeking behaviors.Journal of neurochemistry · 2021Review
- Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex.Scientific reports · 2021Article
- Limited versus extended cocaine intravenous self-administration: Behavioral effects and electrophysiological changes in insular cortex.CNS neuroscience & therapeutics · 2021Article
- Stimulation in the Rat Anterior Insula and Anterior Cingulate During an Effortful Weightlifting Task.Frontiers in neuroscience · 2021Article
- The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex.Neuropharmacology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In substance use disorders, negative affect associated with drug withdrawal can elicit strong drug craving and promote relapse. One brain region implicated in those processes is the rostral agranular insular cortex (RAIC), although precisely how this region encodes negative affect associated with drug seeking is unknown. Here, a preclinical model was used where RAIC activity was examined in male Sprague Dawley rats during intraoral infusions of a sweet (saccharin) paired with impending but delayed access to cocaine self-administration, and for comparative purposes, during the sweet predicting saline self-administration or injection of lithium chloride (LiCl), or during intraoral infusions of a bitter taste (quinine). Consistent with previous work, cocaine-paired saccharin, LiCl-paired saccharin, and quinine all elicited aversive taste reactivity. However, the aversive taste reactivity elicited by the cocaine-paired tastant was qualitatively different from that evoked by the other two agents. Furthermore, differences in taste reactivity were reflected in RAIC cell firing, where distinct shifts in neural signaling were observed specifically after cocaine but not LiCl conditioning. Notably, low motivation for cocaine (indicated by low loading and slower latencies to lever press) was correlated with this shift in RAIC signaling, but aversive (gaping) responses were not. Collectively, these findings indicate that cocaine-paired tastants elicit unique aspects of aversive behaviors that differ from traditional conditioned taste aversion (LiCl) or quinine and that the RAIC plays a role in modulating drug-seeking behaviors driven by drug-induced dysphoria (craving), but not negative affect per se.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.