ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Auditory Predictive Coding across Awareness States under Anesthesia: An Intracranial Electrophysiology Study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.British journal of anaesthesia · 2023Trial
- Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Ontology-constrained multi-LLM scoring of hypothesis support in the predictive processing literature.Research square · 2026Article
- Article
- Stimulus-driven and behavior-driving activity along the cortical auditory hierarchy.NeuroImage · 2026Article
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- Sex- and etiology-specific effects on predictive processing in the inferior colliculus of two rat models of autism.Communications biology · 2026Article
- Cortical deviance detection represents a canonical difference signal.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical substrates of prediction in visual cortical spiking.bioRxiv : the preprint server for biology · 2025Article
- Modulation of Auditory Novelty Processing by Dexmedetomidine and Natural Sleep: A Human Intracranial Electrophysiology Study.The European journal of neuroscience · 2025Article
- Predictive coding: a more cognitive process than we thought?Trends in cognitive sciences · 2025Review
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex.eLife · 2024Article
- Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Touching the unconscious in the unconscious - hypnotic communication with unconscious patients.Frontiers in psychology · 2024Review
- Insights into epileptic aphasia: Intracranial recordings in a child with a left insular ganglioglioma.Epilepsy & behavior reports · 2024Article
- Immediate neural impact and incomplete compensation after semantic hub disconnection.Nature communications · 2023Article
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The systems-level mechanisms underlying loss of consciousness (LOC) under anesthesia remain unclear. General anesthetics suppress sensory responses within higher-order cortex and feedback connections, both critical elements of predictive coding hypotheses of conscious perception. Responses to auditory novelty may offer promise as biomarkers for consciousness. This study examined anesthesia-induced changes in auditory novelty responses over short (local deviant [LD]) and long (global deviant [GD]) time scales, envisioned to engage preattentive and conscious levels of processing, respectively. Electrocorticographic recordings were obtained in human neurosurgical patients (3 male, 3 female) from four hierarchical processing levels: core auditory cortex, non-core auditory cortex, auditory-related, and PFC. Stimuli were vowel patterns incorporating deviants within and across stimuli (LD and GD). Subjects were presented with stimuli while awake, and during sedation (responsive) and following LOC (unresponsive) under propofol anesthesia. LD and GD effects were assayed as the averaged evoked potential and high gamma (70-150 Hz) activity. In the awake state, LD and GD effects were present in all recorded regions, with averaged evoked potential effects more broadly distributed than high gamma activity. Under sedation, LD effects were preserved in all regions, except PFC. LOC was accompanied by loss of LD effects outside of auditory cortex. By contrast, GD effects were markedly suppressed under sedation in all regions and were absent following LOC. Thus, although the presence of GD effects is indicative of being awake, its absence is not indicative of LOC. Loss of LD effects in higher-order cortical areas may constitute an alternative biomarker of LOC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.