Evidence map›Paper›PMID 30126842›Full record

ArticleThe Journal of biological chemistry2018

Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.

Sujitha Duggimpudi, Andreas Kloetgen, Sathish Kumar Maney, Philipp C Münch, Kebria Hezaveh, Hamed Shaykhalishahi, Wolfgang Hoyer, Alice C McHardy, Philipp A Lang, Arndt Borkhardt and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Isoform-Specific Localization Diversifies Human MSI2 Function.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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  5. RNA-binding proteins in bone pathophysiology.Frontiers in cell and developmental biology · 2024
    Review
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  17. [Advances in research of Musashi2 in solid tumors].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sujitha DuggimpudiFrom the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany.ORCID 0000-0001-7835-2450
Andreas KloetgenFrom the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Sathish Kumar ManeyDepartment of Molecular Medicine II, Heinrich Heine University, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
Philipp C MünchDepartment of Algorithmic Bioinformatics, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Kebria HezavehFrom the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Hamed ShaykhalishahiInstitute of Physical Biology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Wolfgang HoyerInstitute of Physical Biology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Alice C McHardyDepartment of Algorithmic Bioinformatics, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Philipp A LangDepartment of Molecular Medicine II, Heinrich Heine University, Universitätsstrasse 1, 40225, Düsseldorf, Germany.
Arndt BorkhardtFrom the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Jessica I HoellFrom the Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Medical Faculty, Heinrich Heine University, Moorenstrasse 5, 40225 Düsseldorf, Germany, Jessica.hoell@med.uni-duesseldorf.de.
Heinrich Heine University Düsseldorf · DEHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA-binding protein Musashi 2 (MSI2) has emerged as an important regulator in cancer initiation, progression, and drug resistance. Translocations and deregulation of the

Indexed as

TranscriptomeBase SequenceBinding SitesCytokine Receptor gp130Epidermal Growth FactorEukaryotic Initiation Factor-2Gene Expression ProfilingGene Expression RegulationHEK293 CellsHepatocyte Growth FactorHumansImmunoprecipitationInterleukin-6LeukemiaLightMitogen-Activated Protein Kinase 1Cytokine Receptor gp130Epidermal Growth FactorEukaryotic Initiation Factor-2Hepatocyte Growth FactorIL6 protein, humanIL6ST protein, humanInterleukin-6MAPK1 protein, humanMAPK3 protein, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MSI2 protein, humanRNA-Binding ProteinsRNA, MessengerSTAT3 protein, humanSTAT3 Transcription Factorcancercancer and Musashi2interleukin 6 (IL-6)Janus kinase (JAK)Janus kinase (JAK)/STAT signalingleukemiamitogen-activated protein kinase (MAPK)mitogen-activated protein kinase (MAPK) signalingMusashi 2PAR-CLIPphosphorylationpost-transcriptional regulationRNA-binding protein

Identifiers

PMID30126842
PMCPMC6177596
OpenAlexW2888453839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.