Evidence map›Paper›PMID 30126841›Full record

ArticleThe Journal of biological chemistry2018

Molecular mechanism of poliovirus Sabin vaccine strain attenuation.

Brian C Avanzino, Helen Jue, Clare M Miller, Emily Cheung, Gabriele Fuchs, Christopher S Fraser

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Viral Live-Attenuated Vaccines (LAVs): Past and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brian C AvanzinoFrom the Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616 and.
Helen JueFrom the Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616 and.
Clare M Millerthe Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York 12222.
Emily Cheungthe Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York 12222.
Gabriele Fuchsthe Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York 12222 gfuchs@albany.edu.
Christopher S FraserFrom the Department of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616 and csfraser@ucdavis.edu.
University of California, Davis · USAlbany State University · USUniversity at Albany, State University of New York · US

Funding

The mechanism of mRNA recruitment to the human ribosome.R01GM092927 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FRASER, CHRISTOPHER S · 2010 to 2022
$4.1M
NIGMS NIH HHS R01 GM092927
6 · The paper itself

Abstract

Recruitment of poliovirus (PV) RNA to the human ribosome requires the coordinated interaction of the viral internal ribosome entry site (IRES) and several host cellular initiation factors and IRES

Indexed as

MutationProtein BiosynthesisAnimalsBaculoviridaeBase SequenceCloning, MolecularEscherichia coliEukaryotic Initiation Factor-4AEukaryotic Initiation Factor-4GGene ExpressionGenes, ReporterGenetic VectorsHeLa CellsHumansInternal Ribosome Entry SitesLuciferasesEukaryotic Initiation Factor-4AEukaryotic Initiation Factor-4GInternal Ribosome Entry SitesLuciferasesPoliovirus Vaccine, OralPolypyrimidine Tract-Binding ProteinRecombinant ProteinsVaccines, Attenuatedeukaryotic initiation factor 4A (eIF4A)eukaryotic translation initiationeukaryotic translation initiation factor 4G (eIF4G)internal ribosome entry site (IRES)plus-stranded RNA viruspoliovirusRNA-binding proteinvaccinevirulence

Identifiers

PMID30126841
PMCPMC6177584
OpenAlexW2888495372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.