ArticleSchizophrenia research2019
Functional connectivity in distinct cognitive subtypes in psychosis.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy.Schizophrenia bulletin · 2026Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Distinct cognitive trajectories in the early course of psychosis are associated with clinical and functional outcomes longitudinally.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models.NPP - digital psychiatry and neuroscience · 2025Article
- Connectome-based fingerprinting: reproducibility, precision, and behavioral prediction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- The distinct functional brain network and its association with psychotic symptom severity in men with methamphetamine-associated psychosis.BMC psychiatry · 2024Article
- Review
- To lump or to split: cognitive impairment across mood and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments.BMC psychiatry · 2023Article
- NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data.Frontiers in neuroinformatics · 2023Article
- Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder.Schizophrenia bulletin · 2022Article
- Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome.Schizophrenia bulletin · 2022Article
- Identifying and revealing different brain neural activities of cognitive subtypes in early course schizophrenia.Frontiers in molecular neuroscience · 2022Article
- The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia.Scientific reports · 2021Article
- The Heterogeneity of Longitudinal Cognitive Decline in Euthymic Bipolar I Disorder With Clinical Characteristics and Functional Outcomes.Frontiers in psychiatry · 2021Article
- Mapping cognitive trajectories across the course of illness in psychosis.Schizophrenia research · 2019Article
- Functional connectomics of affective and psychotic pathology.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundCognitive dysfunction is common in psychotic disorders, and may reflect underlying pathophysiology. However, substantial cognitive heterogeneity exists both within and between diagnostic categories, creating challenges for studying the neurobiology of cognitive dysfunction in patients. The aim of this study was to identify patients with psychosis with intact versus impaired cognitive profiles, and to examine resting state functional connectivity between patient groups and compared to healthy controls to determine the extent to which patterns of connectivity are overlapping or distinct.
methodsParticipants with affective or non-affective psychosis (n=120) and healthy controls (n=31) were administered the MATRICS Consensus Cognitive Battery, clinical and community functioning assessments, and an fMRI scan to measure resting state functional connectivity (RSFC). Cognitive composite scores were used to identify groups of patients with and without cognitive dysfunction. RSFC was compared between groups of patients and healthy controls, controlling for demographic and clinical variables.
resultsBoth cognitively intact and cognitively impaired patients showed decreased intrinsic connectivity compared to controls in frontoparietal control (FPN) and motor networks. Patients with cognitive impairment showed additional reductions in FPN connectivity compared to patients with intact cognition, particularly in subnetwork A.
conclusionsWe leveraged the heterogeneity in cognitive ability among patients with psychosis to disentangle the relative contributions of cognitive dysfunction and presence of an underlying psychotic illness using resting state functional connectivity. These findings suggest at least partially separable effects of presence of a psychotic disorder and neurocognitive impairment contributing to network dysconnectivity in psychosis.
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