ArticleBiological psychiatry2019
Aberrant Middle Prefrontal-Motor Cortex Connectivity Mediates Motor Inhibitory Biomarker in Schizophrenia.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia.Journal of psychiatry & neuroscience : JPNPooled it
- Schizophrenia Pathophysiology: Neurotransmitter Dysfunctions and Biomarker Frontiers.Current topics in medicinal chemistry · 2026Review
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.Brain : a journal of neurology · 2024Article
- Brain Connectivity Signature Extractions from TMS Invoked EEGs.Sensors (Basel, Switzerland) · 2023Article
- Deviant spontaneous neural activity as a potential early-response predictor for therapeutic interventions in patients with schizophrenia.Frontiers in neuroscience · 2023Article
- Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- MiR-4763-3p targetingAging and disease · 2022Article
- Markers of Schizophrenia-A Critical Narrative Update.Journal of clinical medicine · 2022Review
- Alterations of dynamic functional connectivity between visual and executive-control networks in schizophrenia.Brain imaging and behavior · 2022Article
- Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders.International journal of molecular sciences · 2021Review
- Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia.Schizophrenia bulletin · 2021Article
- Assessment of Cortical Plasticity in Schizophrenia by Transcranial Magnetic Stimulation.Neural plasticity · 2021Review
- A Review of Studies Leveraging Multimodal TMS-fMRI Applications in the Pathophysiology and Treatment of Schizophrenia.Frontiers in human neuroscience · 2021Review
- Investigational and Therapeutic Applications of Transcranial Magnetic Stimulation in Schizophrenia.Current psychiatry reports · 2019Review
- Dysfunctional Neural Processes Underlying Context Processing Deficits in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Polymorphisms in Dopaminergic Genes in Schizophrenia and Their Implications in Motor Deficits and Antipsychotic Treatment.Frontiers in neuroscience · 2019Article
- Genetic polymorphism and neuroanatomical changes in schizophrenia.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Article
Corrections and comments
- Erratum issuedErrata.2024
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInhibitory deficits in motor cortex in schizophrenia have been well demonstrated using short-interval intracortical inhibition (SICI) by transcranial magnetic stimulation. However, it remains unknown whether these deficits originate from dysfunction of motor cortex itself or reflect abnormal modulations of motor cortex by other schizophrenia-related brain areas.
methodsThe study was completed by 24 patients with schizophrenia spectrum disorders and 30 healthy control subjects. SICI was obtained by delivering transcranial magnetic stimulation over the left motor cortex. Resting-state functional magnetic resonance imaging and diffusion tensor imaging fractional anisotropy were used to measure functional connectivity (FC) and white matter microstructures, respectively. Stimulation sites for SICI at motor cortex were used as the seeds to obtain whole-brain FC maps. Clinical symptoms were assessed with the Brief Psychiatric Rating Scale.
resultsIn schizophrenia, left prefrontal cortex-motor cortex FC was inversely associated with SICI but positively associated with the underlying white matter microstructure at the left corona radiata and also associated with overall symptoms (all corrected p < .05). Mediation analysis showed that the prefrontal-motor cortex FC significantly mediated the corona radiata white matter effects on SICI (p = .007).
conclusionsHigher resting-state left prefrontal-motor cortex FC, accompanied by a higher fractional anisotropy of left corona radiata, predicted fewer inhibitory deficits, suggesting that the inhibitory deficits in motor cortex in schizophrenia may in part be mediated by a top-down prefrontal influence. SICI may serve as a robust biomarker indexing inhibitory dysfunction at anatomic as well as circuitry levels in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.